BACKGROUND: Efficacy of rotavirus (RV) vaccination is difficult to assess outside of controlled clinical trials. In countries with low-to-moderate RV vaccination coverage, annual variation in RV outbreak might have a stronger influence on morbidity than RV vaccination. METHODS: We analyzed German RV surveillance data from 2006 to 2010 in the 16 federal states of Germany. To overcome the bias of annual variation of RV infections, we analyzed the effects of RV vaccination in Germany by comparing vaccination rate with morbidity as indicated by notification data. RESULTS: RV vaccination coverage in 0- to 1-year-old children in Germany increased from 3% in 2007 to 26% in 2010. The vaccination coverage varied highly between different federal states of Germany (2007, 1%-14%; 2008, 4%-35%, 2009, 8%-52%; and 2010, 17%-64%). There was a significant correlation between RV vaccination coverage and reduction in morbidity (r = -0.66, P = 0.0054) in 0- to <2-year-old children. The proportion of children vaccinated by one of the 2 vaccines, Rotarix and RotaTeq, was similar. Although we found a temporal delay of the epidemic RV seasons 2008 to 2010, those changes remained within the naturally occurring range. CONCLUSIONS: The overall RV vaccination coverage in Germany is still low as compared with other countries with vaccination-supporting policies. Initial data suggest an efficacy of the vaccination.
BACKGROUND: Efficacy of rotavirus (RV) vaccination is difficult to assess outside of controlled clinical trials. In countries with low-to-moderate RV vaccination coverage, annual variation in RV outbreak might have a stronger influence on morbidity than RV vaccination. METHODS: We analyzed German RV surveillance data from 2006 to 2010 in the 16 federal states of Germany. To overcome the bias of annual variation of RV infections, we analyzed the effects of RV vaccination in Germany by comparing vaccination rate with morbidity as indicated by notification data. RESULTS: RV vaccination coverage in 0- to 1-year-old children in Germany increased from 3% in 2007 to 26% in 2010. The vaccination coverage varied highly between different federal states of Germany (2007, 1%-14%; 2008, 4%-35%, 2009, 8%-52%; and 2010, 17%-64%). There was a significant correlation between RV vaccination coverage and reduction in morbidity (r = -0.66, P = 0.0054) in 0- to <2-year-old children. The proportion of children vaccinated by one of the 2 vaccines, Rotarix and RotaTeq, was similar. Although we found a temporal delay of the epidemic RV seasons 2008 to 2010, those changes remained within the naturally occurring range. CONCLUSIONS: The overall RV vaccination coverage in Germany is still low as compared with other countries with vaccination-supporting policies. Initial data suggest an efficacy of the vaccination.
Authors: Kaisa M Kemppainen; Kristian F Lynch; Edwin Liu; Maria Lönnrot; Ville Simell; Thomas Briese; Sibylle Koletzko; William Hagopian; Marian Rewers; Jin-Xiong She; Olli Simell; Jorma Toppari; Anette-G Ziegler; Beena Akolkar; Jeffrey P Krischer; Åke Lernmark; Heikki Hyöty; Eric W Triplett; Daniel Agardh Journal: Clin Gastroenterol Hepatol Date: 2016-11-10 Impact factor: 11.382
Authors: Ui Yoon Choi; Soo Young Lee; Sang Hyuk Ma; Young Taek Jang; Jae Young Kim; Hwang Min Kim; Jong Hyun Kim; Dong Soo Kim; Yong Soo Kim; Jin Han Kang Journal: Eur J Pediatr Date: 2013-02-27 Impact factor: 3.183
Authors: Shannon E MacDonald; Margaret L Russell; Xianfang C Liu; Kimberley A Simmonds; Diane L Lorenzetti; Heather Sharpe; Jill Svenson; Lawrence W Svenson Journal: Hum Vaccin Immunother Date: 2018-12-20 Impact factor: 3.452