BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease among young children in the United States. RSV-associated hospitalization increased among children in the United States during 1980 through 1996. In this study, we updated national estimates of RSV hospitalization rates among US children through 2006. METHODS: We conducted a retrospective analysis of hospital discharges for lower respiratory tract illness (LRTI) in children <5 years old from the National Hospital Discharge Survey. LRTI hospitalizations were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification codes. RSV-coded hospitalizations were International Classification of Diseases, Ninth Revision, Clinical Modification codes 466.11, 480.1, and 079.6. RSV-associated hospitalizations were the sum of RSV-coded hospitalizations and a proportion of hospitalizations coded as bronchiolitis and pneumonia during the RSV season. RESULTS: RSV-coded hospitalizations accounted for 24% of an estimated 5.5 million LRTI hospitalizations among children <5 years of age during the 10 study years, 1997-2006. The RSV-coded hospitalization rate in infants <1 year old was 26.0 per 1000, with no significant difference between study years. The hospitalization rate was highest among infants <3 months old (48.9 per 1000), followed by infants 3 to 5 months old (28.4 per 1000), and lower among those >1 year old (1.8 per 1000). An estimated 132,000 to 172,000 RSV-associated hospitalizations occurred annually in children <5 years of age. CONCLUSION: RSV hospitalization rates remained steady during 1997 to 2006 and were a substantial burden in the United States, especially among infants and young children. A safe and effective RSV vaccine is needed.
BACKGROUND:Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease among young children in the United States. RSV-associated hospitalization increased among children in the United States during 1980 through 1996. In this study, we updated national estimates of RSV hospitalization rates among US children through 2006. METHODS: We conducted a retrospective analysis of hospital discharges for lower respiratory tract illness (LRTI) in children <5 years old from the National Hospital Discharge Survey. LRTI hospitalizations were identified by using International Classification of Diseases, Ninth Revision, Clinical Modification codes. RSV-coded hospitalizations were International Classification of Diseases, Ninth Revision, Clinical Modification codes 466.11, 480.1, and 079.6. RSV-associated hospitalizations were the sum of RSV-coded hospitalizations and a proportion of hospitalizations coded as bronchiolitis and pneumonia during the RSV season. RESULTS:RSV-coded hospitalizations accounted for 24% of an estimated 5.5 million LRTI hospitalizations among children <5 years of age during the 10 study years, 1997-2006. The RSV-coded hospitalization rate in infants <1 year old was 26.0 per 1000, with no significant difference between study years. The hospitalization rate was highest among infants <3 months old (48.9 per 1000), followed by infants 3 to 5 months old (28.4 per 1000), and lower among those >1 year old (1.8 per 1000). An estimated 132,000 to 172,000 RSV-associated hospitalizations occurred annually in children <5 years of age. CONCLUSION:RSV hospitalization rates remained steady during 1997 to 2006 and were a substantial burden in the United States, especially among infants and young children. A safe and effective RSV vaccine is needed.
Authors: Srirupa Chatterjee; Priya Luthra; Ekaterina Esaulova; Eugene Agapov; Benjamin C Yen; Dominika M Borek; Megan R Edwards; Anuradha Mittal; David S Jordan; Parameshwar Ramanan; Martin L Moore; Rohit V Pappu; Michael J Holtzman; Maxim N Artyomov; Christopher F Basler; Gaya K Amarasinghe; Daisy W Leung Journal: Nat Microbiol Date: 2017-06-30 Impact factor: 17.745
Authors: Lindsay Kim; Brian Rha; Jon S Abramson; Larry J Anderson; Carrie L Byington; Grace L Chen; John DeVincenzo; Kathryn M Edwards; Janet A Englund; Ann R Falsey; Marie R Griffin; Ruth A Karron; Karen G Martin; H Cody Meissner; Flor M Munoz; Andrew T Pavia; Pedro A Piedra; William Schaffner; Eric A F Simões; Rosalyn Singleton; H Keipp Talbot; Edward E Walsh; Jane R Zucker; Susan I Gerber Journal: Clin Infect Dis Date: 2017-09-15 Impact factor: 9.079
Authors: Edward Goldstein; Hieu H Nguyen; Patrick Liu; Cecile Viboud; Claudia A Steiner; Colin J Worby; Marc Lipsitch Journal: J Infect Dis Date: 2018-01-04 Impact factor: 5.226
Authors: Wouter A A de Steenhuijsen Piters; Santtu Heinonen; Raiza Hasrat; Eleonora Bunsow; Bennett Smith; Maria-Carmen Suarez-Arrabal; Damien Chaussabel; Daniel M Cohen; Elisabeth A M Sanders; Octavio Ramilo; Debby Bogaert; Asuncion Mejias Journal: Am J Respir Crit Care Med Date: 2016-11-01 Impact factor: 21.405