Literature DB >> 218173

Aminonucleosides and their derivatives. IV. Synthesis of the 3'-amino-3'-deoxynucleoside 5'-phosphates.

A V Azhayev, A M Ozols, A S Bushnev, N B Dyatkina, S V Kochetkova, L S Victorova, M K Kukhanova, A A Krayevsky, B P Gottikh.   

Abstract

A new procedure has been developed for the synthesis of 3'-amino-3'-deoxyribonucleosides of adenine, cytosine and uracil by condensing the trimethylsilylated bases with peracylated 3-azido-3-deoxyribose derivative. The azido group could subsequently be reduced to amino. The 5'-phosphates of these nucleosides have been prepared and the analogues have been tested for their ability to stimulate the ribosome-catalyzed reaction of 3'(2')-O-(N-formylmethionyl) adenosine 5'-phosphate with phenylalanyl-tRNA.

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Year:  1979        PMID： 218173      PMCID： PMC327717          DOI： 10.1093/nar/6.2.625

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  6 in total

1.  Preparation of a substituted 3-acetamido-3-deoxy-D-ribofuranosyl bromide suitable for the synthesis of puromycin analogs.

Authors:  H S Khadem; T D Audichya; E S Ashry; R Sindric
Journal:  Carbohydr Res       Date:  1975-05       Impact factor: 2.104

2.  A general synthesis of N-glycosides. 6. On the mechanism of the stannic chloride catalyzed silyl Hilbert-Johnson reaction.

Authors:  U Niedballa; H Vorbrüggen
Journal:  J Org Chem       Date:  1976-06-11       Impact factor: 4.354

3.  A novel procedure for the synthesis of 2'-O-alkyl nucleotides.

Authors:  I Tazawa; S Tazawa; J L Alderfer; P O Ts'o
Journal:  Biochemistry       Date:  1972-12-19       Impact factor: 3.162

4.  Conformational analysis of the sugar ring in nucleosides and nucleotides. Improved method for the interpretation of proton magnetic resonance coupling constants.

Authors:  C Altona; M Sundaralingam
Journal:  J Am Chem Soc       Date:  1973-04-04       Impact factor: 15.419

5.  Amino acids are not all initially attached to the same position on transfer RNA molecules.

Authors:  T H Fraser; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

6.  Effect of cytidine-5'-monophosphate on peptidyl transferase activity.

Authors:  J Cerná
Journal:  FEBS Lett       Date:  1975-10-15       Impact factor: 4.124
  6 in total
  6 in total

1.  New fluorescent dyes in the red region for biodiagnostics.

Authors:  M Sauer; K T Han; R Müller; S Nord; A Schulz; S Seeger; J Wolfrum; J Arden-Jacob; G Deltau; N J Marx; C Zander; K H Drexhage
Journal:  J Fluoresc       Date:  1995-09       Impact factor: 2.217

2.  Oligomerization of activated derivatives of 3'-amino-3'-deoxyguanosine on poly(C) and poly(dC) templates.

Authors:  W S Zielinski; L E Orgel
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

3.  The synthesis of protected 5'-amino-2',5'-dideoxyribonucleoside-3'-O-phosphoramidites; applications of 5'-amino-oligodeoxyribonucleotides.

Authors:  B S Sproat; B Beijer; P Rider
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

4.  Thiol reduction of 3'-azidothymidine to 3'-aminothymidine: kinetics and biomedical implications.

Authors:  A L Handlon; N J Oppenheimer
Journal:  Pharm Res       Date:  1988-05       Impact factor: 4.200

5.  Oligoaminonucleoside phosphoramidates. Oligomerization of dimers of 3'-amino-3'-deoxy-nucleotides (GC and CG) in aqueous solution.

Authors:  W S Zielinski; L E Orgel
Journal:  Nucleic Acids Res       Date:  1987-02-25       Impact factor: 16.971

6.  Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

Authors:  K A Jacobson; Z G Gao; A Chen; D Barak; S A Kim; K Lee; A Link; P V Rompaey; S van Calenbergh; B T Liang
Journal:  J Med Chem       Date:  2001-11-22       Impact factor: 7.446
  6 in total

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