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Literature DB >> 218172

Characterization of the genomic RNA from a Rous sarcoma virus mutant temperature sensitive for cell transformation.

J L Darlix, M Levray, P A Bromley, P F Spahr.

Abstract

We have found that the LA23 t/s mutant of Rous sarcoma virus (phenotype Prague B), even when passaged repeatedly at high multiplicity of infection, does not give rise to transformation defective deletion mutants comparable to those derived from RSV. In view of this fact and of the high rate of production of this mutant at 41 degrees C, we have undertaken a detailed analysis of the genome of this virus by ordering all large T1 oligonucleotides and by determining their nucleotide sequences. The results indicate a high degree of mutation in the onc gene as compared to that of Pr-A or Pr-B.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1979 PMID： 218172 PMCID： PMC327708 DOI： 10.1093/nar/6.2.471

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

15 in total

1. Heteroduplex analysis of avian RNA tumor viruses.

Authors: R P Junghans; S Hu; C A Knight; N Davidson
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

2. Occurrence of partial deletion and substitution of the src gene in the RNA genome of avian sarcoma virus.

Authors: M M Lai; S S Hu; P K Vogt
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

3. New rapid gel sequencing method for RNA.

Authors: A Simoncsits; G G Brownlee; R S Brown; J R Rubin; H Guilley
Journal: Nature Date: 1977-10-27 Impact factor: 49.962

4. A sequence of 50 nucleotides from coliphage R17 RNA.

Authors: U F Rensing; G G Schoenmakers
Journal: Eur J Biochem Date: 1973-02-15

5. The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants.

Authors: G S Martin; P H Duesberg
Journal: Virology Date: 1972-02 Impact factor: 3.616

6. Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses.

Authors: P K Vogt
Journal: Virology Date: 1971-12 Impact factor: 3.616

7. Enzymes for RNA sequence analysis. Preparation and specificity of exoplasmodial ribonucleases I and II from Physarum polycephalum.

Authors: D Pilly; A Niemeyer; M Schmidt; J P Bargetzi
Journal: J Biol Chem Date: 1978-01-25 Impact factor: 5.157

8. Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H.

Authors: J L Darlix; P A Bromley; P F Spahr
Journal: J Virol Date: 1977-09 Impact factor: 5.103

7. A cellular protein phosphorylated by the avian sarcoma virus transforming gene product is associated with ribonucleoprotein particles.

Authors: A P Arrigo; J L Darlix; P F Spahr
Journal: EMBO J Date: 1983 Impact factor: 11.598

8. Characterization of the prosome from Drosophila and its similarity to the cytoplasmic structures formed by the low molecular weight heat-shock proteins.

Authors: A P Arrigo; J L Darlix; E W Khandjian; M Simon; P F Spahr
Journal: EMBO J Date: 1985-02 Impact factor: 11.598

8 in total

Characterization of the genomic RNA from a Rous sarcoma virus mutant temperature sensitive for cell transformation.

1. Heteroduplex analysis of avian RNA tumor viruses.

2. Occurrence of partial deletion and substitution of the src gene in the RNA genome of avian sarcoma virus.

3. New rapid gel sequencing method for RNA.

4. A sequence of 50 nucleotides from coliphage R17 RNA.

5. The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants.

6. Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses.

7. Enzymes for RNA sequence analysis. Preparation and specificity of exoplasmodial ribonucleases I and II from Physarum polycephalum.

8. Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H.

9. Mapping adenines, guanines, and pyrimidines in RNA.

10. New procedure for the direct analysis of in vitro reverse transcription of Rous sarcoma virus RNA.

1. New procedure for isolation of Rous sarcoma virus-specific RNA from infected cells.

2. A 20S particle ubiquitous from yeast to human.

3. A model structure for Rous sarcoma virus genomic RNA and its implication for various functions of the viral RNA.

4. High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome.

5. Nucleotide sequence and structure of cytoplasmic 5S RNA and 5.8S RNA of Chlamydomonas reinhardii.

6. Analysis of the secondary and tertiary structures of Rous sarcoma virus RNA.

7. A cellular protein phosphorylated by the avian sarcoma virus transforming gene product is associated with ribonucleoprotein particles.

8. Characterization of the prosome from Drosophila and its similarity to the cytoplasmic structures formed by the low molecular weight heat-shock proteins.