BACKGROUND AND PURPOSE: Endovascular treatment of ischemic stroke usually involves recombinant tissue-type plasminogen activator (rtPA)-mediated thrombolysis in anesthetized patients. Paradoxically, differential influences of anesthetic agents on thrombolysis outcome remain unknown. METHODS: In situ thrombotic stroke was induced in mice by local injection of thrombin. Four hours after the ischemic onset, mice underwent rtPA-mediated thrombolysis either awake or subjected to different anesthetic regimens (propofol, isoflurane/N2O, ketamine). Infarct volume and arterial recanalization were assessed by MRI at 24 hours. RESULTS: Whatever the anesthetic regimen, infarct volumes measured at 24 hours were not affected. However, in contrast with other anesthetic agents tested, ketamine dramatically reduced infarct volume when combined with rtPA. CONCLUSIONS: Altogether these data suggest that ketamine significantly improves the benefit of rtPA-induced thrombolysis after stroke.
BACKGROUND AND PURPOSE: Endovascular treatment of ischemic stroke usually involves recombinant tissue-type plasminogen activator (rtPA)-mediated thrombolysis in anesthetized patients. Paradoxically, differential influences of anesthetic agents on thrombolysis outcome remain unknown. METHODS: In situ thrombotic stroke was induced in mice by local injection of thrombin. Four hours after the ischemic onset, mice underwent rtPA-mediated thrombolysis either awake or subjected to different anesthetic regimens (propofol, isoflurane/N2O, ketamine). Infarct volume and arterial recanalization were assessed by MRI at 24 hours. RESULTS: Whatever the anesthetic regimen, infarct volumes measured at 24 hours were not affected. However, in contrast with other anesthetic agents tested, ketamine dramatically reduced infarct volume when combined with rtPA. CONCLUSIONS: Altogether these data suggest that ketamine significantly improves the benefit of rtPA-induced thrombolysis after stroke.
Authors: Sara Martinez de Lizarrondo; Clément Gakuba; Bradley A Herbig; Yohann Repessé; Carine Ali; Cécile V Denis; Peter J Lenting; Emmanuel Touzé; Scott L Diamond; Denis Vivien; Maxime Gauberti Journal: Circulation Date: 2017-05-09 Impact factor: 29.690
Authors: Emmanuel Touzé; Denis Vivien; Cyrille Orset; Benoit Haelewyn; Stuart M Allan; Saema Ansar; Francesco Campos; Tae Hee Cho; Anne Durand; Mohamad El Amki; Marc Fatar; Isaac Garcia-Yébenes; Maxime Gauberti; Saskia Grudzenski; Ignacio Lizasoain; Eng Lo; Richard Macrez; Isabelle Margaill; Samaneh Maysami; Stephen Meairs; Norbert Nighoghossian; Josune Orbe; Jose Antonio Paramo; Jean-Jacques Parienti; Nancy J Rothwell; Marina Rubio; Christian Waeber; Alan R Young Journal: Stroke Date: 2016-03-31 Impact factor: 7.914
Authors: Julie Belliere; Sara Martinez de Lizarrondo; Robin P Choudhury; Aurélien Quenault; Audrey Le Béhot; Christine Delage; Dominique Chauveau; Joost P Schanstra; Jean-Loup Bascands; Denis Vivien; Maxime Gauberti Journal: Theranostics Date: 2015-08-08 Impact factor: 11.556
Authors: Maxime Gauberti; Antoine P Fournier; Fabian Docagne; Denis Vivien; Sara Martinez de Lizarrondo Journal: Theranostics Date: 2018-02-02 Impact factor: 11.556