Literature DB >> 21816271

Regulatory revolution: evolving the "anti-LacI" repressor.

Christopher J Marx1.   

Abstract

Much of adaptation is based upon changes in gene expression, but the emergence of new regulatory logic has not been observed directly. Now, Poelwijk et al. report evolving the lac repressor (LacI) to reverse its regulatory logic, resulting in an "anti-LacI" that represses transcription when bound to its "inducer."
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21816271      PMCID： PMC3152793          DOI： 10.1016/j.cell.2011.07.015

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme.

Authors:  Eric J Hayden; Evandro Ferrada; Andreas Wagner
Journal:  Nature       Date:  2011-06-02       Impact factor: 49.962

2.  Diminishing returns epistasis among beneficial mutations decelerates adaptation.

Authors:  Hsin-Hung Chou; Hsuan-Chao Chiu; Nigel F Delaney; Daniel Segrè; Christopher J Marx
Journal:  Science       Date:  2011-06-03       Impact factor: 47.728

3.  Darwinian evolution can follow only very few mutational paths to fitter proteins.

Authors:  Daniel M Weinreich; Nigel F Delaney; Mark A Depristo; Daniel L Hartl
Journal:  Science       Date:  2006-04-07       Impact factor: 47.728

4.  Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.

Authors:  Sean B Carroll
Journal:  Cell       Date:  2008-07-11       Impact factor: 41.582

5.  Genome evolution and adaptation in a long-term experiment with Escherichia coli.

Authors:  Jeffrey E Barrick; Dong Su Yu; Sung Ho Yoon; Haeyoung Jeong; Tae Kwang Oh; Dominique Schneider; Richard E Lenski; Jihyun F Kim
Journal:  Nature       Date:  2009-10-18       Impact factor: 49.962

6.  Negative epistasis between beneficial mutations in an evolving bacterial population.

Authors:  Aisha I Khan; Duy M Dinh; Dominique Schneider; Richard E Lenski; Tim F Cooper
Journal:  Science       Date:  2011-06-03       Impact factor: 47.728

7.  Tradeoffs and optimality in the evolution of gene regulation.

Authors:  Frank J Poelwijk; Marjon G J de Vos; Sander J Tans
Journal:  Cell       Date:  2011-07-28       Impact factor: 41.582

8.  Two developmental modules establish 3D beak-shape variation in Darwin's finches.

Authors:  Ricardo Mallarino; Peter R Grant; B Rosemary Grant; Anthony Herrel; Winston P Kuo; Arhat Abzhanov
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-22       Impact factor: 11.205

9.  Mutational robustness can facilitate adaptation.

Authors:  Jeremy A Draghi; Todd L Parsons; Günter P Wagner; Joshua B Plotkin
Journal:  Nature       Date:  2010-01-21       Impact factor: 49.962

10.  Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli.

Authors:  Zachary D Blount; Christina Z Borland; Richard E Lenski
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-04       Impact factor: 11.205
  10 in total
  1 in total

Review 1.  Synthetic approaches to understanding biological constraints.

Authors:  Andrea Velenich; Jeff Gore
Journal:  Curr Opin Chem Biol       Date:  2012-06-08       Impact factor: 8.822
  1 in total

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