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Literature DB >> 21816270

A prion-like trigger of antiviral signaling.

Abstract

The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.

Entities: CellLine Chemical Disease Species

Year: 2011 PMID： 21816270 PMCID： PMC4272580 DOI： 10.1016/j.cell.2011.07.018

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

10 in total

Review 1. Prions.

Authors: David W Colby; Stanley B Prusiner
Journal: Cold Spring Harb Perspect Biol Date: 2011-01-01 Impact factor: 10.005

2. Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins.

Authors: Ferdinando Fiumara; Luana Fioriti; Eric R Kandel; Wayne A Hendrickson
Journal: Cell Date: 2010-12-23 Impact factor: 41.582

3. Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.

Authors: Kausik Si; Yun-Beom Choi; Erica White-Grindley; Amitabha Majumdar; Eric R Kandel
Journal: Cell Date: 2010-02-05 Impact factor: 41.582

4. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Authors: Wenwen Zeng; Lijun Sun; Xiaomo Jiang; Xiang Chen; Fajian Hou; Anirban Adhikari; Ming Xu; Zhijian J Chen
Journal: Cell Date: 2010-04-16 Impact factor: 41.582

5. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

Authors: Rashu B Seth; Lijun Sun; Chee-Kwee Ea; Zhijian J Chen
Journal: Cell Date: 2005-09-09 Impact factor: 41.582

6. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Authors: Fajian Hou; Lijun Sun; Hui Zheng; Brian Skaug; Qiu-Xing Jiang; Zhijian J Chen
Journal: Cell Date: 2011-07-21 Impact factor: 41.582

7. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

Authors: Wenwen Zeng; Ming Xu; Siqi Liu; Lijun Sun; Zhijian J Chen
Journal: Mol Cell Date: 2009-10-23 Impact factor: 17.970

Review 8. The role of ubiquitin in NF-kappaB regulatory pathways.

Authors: Brian Skaug; Xiaomo Jiang; Zhijian J Chen
Journal: Annu Rev Biochem Date: 2009 Impact factor: 23.643

9. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Authors: Kausik Si; Maurizio Giustetto; Amit Etkin; Ruby Hsu; Agnieszka M Janisiewicz; Maria Conchetta Miniaci; Joung-Hun Kim; Huixiang Zhu; Eric R Kandel
Journal: Cell Date: 2003-12-26 Impact factor: 41.582

10. Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain.

Authors: Jane A Potter; Richard E Randall; Garry L Taylor
Journal: BMC Struct Biol Date: 2008-02-28