Literature DB >> 2181491

Drug glucosidation.

B K Tang1.   

Abstract

A number of studies have shown that drug glucosidation occurs in vertebrates. This review summarizes information on the chemical, physical and biological properties of eleven drug glucosides. Three out of two hundred individuals exhibited a complete lack of amobarbital-N-glucoside formation. The data from a pair of identical twins who were deficient in this metabolic pathway suggested the presence of a recessive trait controlled by a single pair of autosomal genes which regulate N-glucoside formation. In addition, average values seemed to be subject to interethnic variation.

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Year:  1990        PMID： 2181491     DOI： 10.1016/0163-7258(90)90034-y

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  7 in total

1.  Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil.

Authors:  M Shipkova; V W Armstrong; E Wieland; P D Niedmann; E Schütz; G Brenner-Weiss; M Voihsel; F Braun; M Oellerich
Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

2.  Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes.

Authors:  M Shipkova; C P Strassburg; F Braun; F Streit; H J Gröne; V W Armstrong; R H Tukey; M Oellerich; E Wieland
Journal:  Br J Pharmacol       Date:  2001-03       Impact factor: 8.739

3.  Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling.

Authors:  Dan Yao; Xiaolei Shi; Lei Wang; Blake A Gosnell; Chi Chen
Journal:  Drug Metab Dispos       Date:  2012-10-03       Impact factor: 3.922

4.  Identification of the diastereomers of pentobarbital N-glucosides excreted in human urine.

Authors:  W H Soine; P J Soine; T M England; R M Graham; G Capps
Journal:  Pharm Res       Date:  1994-11       Impact factor: 4.200

5.  Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.

Authors:  Andreas Brunschweiger; Jamshed Iqbal; Frank Umbach; Anja B Scheiff; Mercedes N Munkonda; Jean Sévigny; Aileen F Knowles; Christa E Müller
Journal:  J Med Chem       Date:  2008-07-17       Impact factor: 7.446

6.  Phenobarbital N-glucosylation by human liver microsomes.

Authors:  Sheela G Paibir; William H Soine; Diana F Thomas; Robert A Fisher
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Jan-Mar       Impact factor: 2.441

7.  Urinary excretion of phenobarbitone and its metabolites in chronically treated patients.

Authors:  I Bernus; R G Dickinson; W D Hooper; M J Eadie
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953
  7 in total

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