BACKGROUND: PCL carries a poor prognosis and the optimal management remains unknown. PATIENTS AND METHODS: To evaluate the outcome of patients with PCL in the era of novel agents and innovative transplantation strategies, we conducted a review of patients with PCL who were treated at our institution from August 2003 to October 2009. Our primary endpoint was to determine overall survival, which was calculated from time of PCL diagnosis to death or last follow-up. Secondary endpoints included response rates and analyses regarding how the novel agents and presence of adverse cytogenetic analyses affected outcomes. RESULTS: We identified 25 patients with PCL (13 with primary PCL [pPCL], 12 with secondary PCL [sPCL]) from our institution. Eighteen patients received bortezomib-based regimens, 19 received high-dose melphalan followed by autologous hematopoietic stem cell transplantation (HCT), and 6 underwent allogeneic HCT. The median overall survival for all patients was 23.6 months. Bortezomib-treated patients had a median survival of 28.4 months vs. 4.0 months for the non-bortezomib-treated group (P < .001). CONCLUSIONS: Our analysis suggests that patients with PCL who were treated with bortezomib and/or allogeneic HCT had improved outcomes.
BACKGROUND:PCL carries a poor prognosis and the optimal management remains unknown. PATIENTS AND METHODS: To evaluate the outcome of patients with PCL in the era of novel agents and innovative transplantation strategies, we conducted a review of patients with PCL who were treated at our institution from August 2003 to October 2009. Our primary endpoint was to determine overall survival, which was calculated from time of PCL diagnosis to death or last follow-up. Secondary endpoints included response rates and analyses regarding how the novel agents and presence of adverse cytogenetic analyses affected outcomes. RESULTS: We identified 25 patients with PCL (13 with primary PCL [pPCL], 12 with secondary PCL [sPCL]) from our institution. Eighteen patients received bortezomib-based regimens, 19 received high-dose melphalan followed by autologous hematopoietic stem cell transplantation (HCT), and 6 underwent allogeneic HCT. The median overall survival for all patients was 23.6 months. Bortezomib-treated patients had a median survival of 28.4 months vs. 4.0 months for the non-bortezomib-treated group (P < .001). CONCLUSIONS: Our analysis suggests that patients with PCL who were treated with bortezomib and/or allogeneic HCT had improved outcomes.
Authors: P Musto; V Simeon; M C Martorelli; M T Petrucci; N Cascavilla; F Di Raimondo; T Caravita; F Morabito; M Offidani; A Olivieri; G Benevolo; R Mina; R Guariglia; G D'Arena; G Mansueto; N Filardi; F Nobile; A Levi; A Falcone; M Cavalli; G Pietrantuono; O Villani; S Bringhen; P Omedè; R Lerose; L Agnelli; K Todoerti; A Neri; M Boccadoro; A Palumbo Journal: Leukemia Date: 2013-08-20 Impact factor: 11.528
Authors: Wilson I Gonsalves; S Vincent Rajkumar; Ronald S Go; Angela Dispenzieri; Vinay Gupta; Preet P Singh; Francis K Buadi; Martha Q Lacy; Prashant Kapoor; David Dingli; John A Lust; Steven R Zeldenrust; Suzanne R Hayman; Robert A Kyle; Morie A Gertz; Shaji K Kumar Journal: Blood Date: 2014-06-23 Impact factor: 22.113
Authors: C Fernández de Larrea; R A Kyle; B G M Durie; H Ludwig; S Usmani; D H Vesole; R Hajek; J F San Miguel; O Sezer; P Sonneveld; S K Kumar; A Mahindra; R Comenzo; A Palumbo; A Mazumber; K C Anderson; P G Richardson; A Z Badros; J Caers; M Cavo; X LeLeu; M A Dimopoulos; C S Chim; R Schots; A Noeul; D Fantl; U-H Mellqvist; O Landgren; A Chanan-Khan; P Moreau; R Fonseca; G Merlini; J J Lahuerta; J Bladé; R Z Orlowski; J J Shah Journal: Leukemia Date: 2012-11-21 Impact factor: 11.528
Authors: Mohammad Bader Obeidat; Ali Mohammad Al-Swailmeen; Abdulmajeed Mohammad Arabeat; Ayman Sulaiman Abukamar Journal: Pan Afr Med J Date: 2020-05-12