Ling Sun1, Wei Ran Li. 1. Department of Orthodontics, Peking University School of Stomatology, Beijing, China.
Abstract
OBJECTIVE: To evaluate the skeletal maturation of male children with orofacial clefts using the cervical vertebral maturation (CVM) method. DESIGN: Case-control study. SETTING: The School of Stomatology, Peking University. PATIENTS: Subjects were 443 boys with cleft lip and/or cleft palate (CL/P) aged 8 to 16 years who were compared with 1772 boys without clefts in an age-matched control group. RESULTS: The 8- to 10-year-old boys of both groups were in CS1. Most of the 11- to 14-year-old boys without CL/P were in CS3 and CS4, though it was not so obvious in boys with CL/P. Most 15- to 16-year-old boys without CL/P were in CS5 and CS6, while there were a lot of boys with CL/P who were still in cervical stages before CS5. Clefts had a significant effect on growth, and boys without CL/P were 1.737 times more likely to have achieved higher cervical stages. From Mann-Whitney test of every age phase, the difference existed in each year of the age range of 11 to 16 years, except from 12 to 13 years (p = .100). In these age phases, the cervical stages of boys with CL/P were lower than those for boys without CL/P. By the age of 14, children with CL/P had a 4.679 times higher risk of delayed CS3, and the 95% confidence interval for the odds ratio was 2.129 to 10.286. CONCLUSIONS: Boys with CL/P are at a higher risk of delayed growth period and retarded pubertal growth peak.
OBJECTIVE: To evaluate the skeletal maturation of male children with orofacial clefts using the cervical vertebral maturation (CVM) method. DESIGN: Case-control study. SETTING: The School of Stomatology, Peking University. PATIENTS: Subjects were 443 boys with cleft lip and/or cleft palate (CL/P) aged 8 to 16 years who were compared with 1772 boys without clefts in an age-matched control group. RESULTS: The 8- to 10-year-old boys of both groups were in CS1. Most of the 11- to 14-year-old boys without CL/P were in CS3 and CS4, though it was not so obvious in boys with CL/P. Most 15- to 16-year-old boys without CL/P were in CS5 and CS6, while there were a lot of boys with CL/P who were still in cervical stages before CS5. Clefts had a significant effect on growth, and boys without CL/P were 1.737 times more likely to have achieved higher cervical stages. From Mann-Whitney test of every age phase, the difference existed in each year of the age range of 11 to 16 years, except from 12 to 13 years (p = .100). In these age phases, the cervical stages of boys with CL/P were lower than those for boys without CL/P. By the age of 14, children with CL/P had a 4.679 times higher risk of delayed CS3, and the 95% confidence interval for the odds ratio was 2.129 to 10.286. CONCLUSIONS:Boys with CL/P are at a higher risk of delayed growth period and retarded pubertal growth peak.
Authors: Laurent A M Thierens; Laura Manalili; Noëmi De Roo; An Verdonck; Maria Cadenas De Llano-Pérula; Guy A M De Pauw Journal: Clin Oral Investig Date: 2021-01-23 Impact factor: 3.573