Literature DB >> 21812630

Severe difficulties with word recognition in noise after platinum chemotherapy in childhood, and improvements with open-fitting hearing-aids.

Einar-Jón Einarsson1, Hannes Petersen, Thomas Wiebe, Per-Anders Fransson, Måns Magnusson, Christian Moëll.   

Abstract

OBJECTIVE: To investigate word recognition in noise in subjects treated in childhood with chemotherapy, study benefits of open-fitting hearing-aids for word recognition, and investigate whether self-reported hearing-handicap corresponded to subjects' word recognition ability.
DESIGN: Subjects diagnosed with cancer and treated with platinum-based chemotherapy in childhood underwent audiometric evaluations. STUDY SAMPLE: Fifteen subjects (eight females and seven males) fulfilled the criteria set for the study, and four of those received customized open-fitting hearing-aids.
RESULTS: Subjects with cisplatin-induced ototoxicity had severe difficulties recognizing words in noise, and scored as low as 54% below reference scores standardized for age and degree of hearing loss. Hearing-impaired subjects' self-reported hearing-handicap correlated significantly with word recognition in a quiet environment but not in noise. Word recognition in noise improved markedly (up to 46%) with hearing-aids, and the self-reported hearing-handicap and disability score were reduced by more than 50%.
CONCLUSIONS: This study demonstrates the importance of testing word recognition in noise in subjects treated with platinum-based chemotherapy in childhood, and to use specific custom-made questionnaires to evaluate the experienced hearing-handicap. Open-fitting hearing-aids are a good alternative for subjects suffering from poor word recognition in noise.

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Year:  2011        PMID: 21812630     DOI: 10.3109/14992027.2011.585667

Source DB:  PubMed          Journal:  Int J Audiol        ISSN: 1499-2027            Impact factor:   2.117


  8 in total

1.  Cisplatin-induced ototoxicity and the role of pharmacogenetic testing.

Authors:  Lauren E Wyatt; Mary Jayne Kennedy
Journal:  J Pediatr Pharmacol Ther       Date:  2012-10

Review 2.  Evaluation and Management of Hearing Loss in Survivors of Childhood and Adolescent Cancers: A Report From the Children's Oncology Group.

Authors:  Johnnie K Bass; Kristin R Knight; Torunn I Yock; Kay W Chang; Douglas Cipkala; Satkiran S Grewal
Journal:  Pediatr Blood Cancer       Date:  2016-02-29       Impact factor: 3.167

Review 3.  Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review.

Authors:  Daniel Stark; Abby R Rosenberg; Donna Johnston; Kristin Knight; Lizzie Caperon; Elizabeth Uleryk; A Lindsay Frazier; Lillian Sung
Journal:  J Speech Lang Hear Res       Date:  2016-10-01       Impact factor: 2.297

4.  Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin.

Authors:  T F Spracklen; A A Vorster; L Ramma; S Dalvie; R S Ramesar
Journal:  Pharmacogenomics J       Date:  2016-07-26       Impact factor: 3.550

Review 5.  Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium.

Authors:  Eva Clemens; Marry M van den Heuvel-Eibrink; Renée L Mulder; Leontien C M Kremer; Melissa M Hudson; Roderick Skinner; Louis S Constine; Johnnie K Bass; Claudia E Kuehni; Thorsten Langer; Elvira C van Dalen; Edith Bardi; Nicolas-Xavier Bonne; Penelope R Brock; Beth Brooks; Bruce Carleton; Eric Caron; Kay W Chang; Karen Johnston; Kristin Knight; Paul C Nathan; Etan Orgel; Pinki K Prasad; Jan Rottenberg; Katrin Scheinemann; Andrica C H de Vries; Thomas Walwyn; Annette Weiss; Antoinette Am Zehnhoff-Dinnesen; Richard J Cohn; Wendy Landier
Journal:  Lancet Oncol       Date:  2019-01       Impact factor: 54.433

6.  Decreased postural control in adult survivors of childhood cancer treated with chemotherapy.

Authors:  Einar-Jón Einarsson; Mitesh Patel; Hannes Petersen; Thomas Wiebe; Per-Anders Fransson; Måns Magnusson; Christian Moëll
Journal:  Sci Rep       Date:  2016-11-10       Impact factor: 4.379

7.  Elevated visual dependency in young adults after chemotherapy in childhood.

Authors:  Einar-Jón Einarsson; Mitesh Patel; Hannes Petersen; Thomas Wiebe; Per-Anders Fransson; Måns Magnusson; Christian Moëll
Journal:  PLoS One       Date:  2018-02-21       Impact factor: 3.240

8.  A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study.

Authors:  Franciscus A Diepstraten; Annelot Jm Meijer; Martine van Grotel; Sabine LA Plasschaert; Alexander E Hoetink; Marta Fiocco; Geert O Janssens; Robert J Stokroos; Marry M van den Heuvel-Eibrink
Journal:  JMIR Res Protoc       Date:  2022-04-07
  8 in total

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