| Literature DB >> 21812096 |
Rebecca Sims1, Sarah Dwyer, Denise Harold, Amy Gerrish, Paul Hollingworth, Jade Chapman, Nicola Jones, Richard Abraham, Dobril Ivanov, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Charlene Thomas, Alexandra Stretton, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuiness, Stephen Todd, Janet A Johnston, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, John Hardy, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Lesley Jones, Peter A Holmans, Michael O'Donovan, Michael J Owen, Julie Williams.
Abstract
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.Entities:
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Year: 2011 PMID： 21812096 DOI： 10.1002/ajmg.b.31216
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568