Literature DB >> 21811928

The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.

Kyoung-Tae Lee1, Tae Woo Jung, Hak-Ju Lee, Seul-Gi Kim, Yu-Su Shin, Wan-Kyunn Whang.   

Abstract

Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.

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Year:  2011        PMID： 21811928     DOI： 10.1007/s12272-011-0719-6

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  28 in total

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Authors:  Olusola Olalekan Elekofehinti; Idowu Olaposi Omotuyi; Jean Paul Kamdem; Oluwamodupe Cecilia Ejelonu; Guimarae Vanessa Alves; Isaac Gbadura Adanlawo; João Batista Teixeira Rocha
Journal:  J Physiol Biochem       Date:  2014-02-25       Impact factor: 4.158

2.  Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression.

Authors:  Qi Huang; Ting Wang; He-Yao Wang
Journal:  Acta Pharmacol Sin       Date:  2016-12-26       Impact factor: 6.150

3.  The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A.

Authors:  Shuai Guo; Yafei F Chen; Sai Shi; Chunli L Pang; Xuzhao Z Wang; Hailin L Zhang; Yong Zhan; Hailong L An
Journal:  Biophys J       Date:  2019-11-21       Impact factor: 4.033

4.  Paving the Road Toward Exploiting the Therapeutic Effects of Ginsenosides: An Emphasis on Autophagy and Endoplasmic Reticulum Stress.

Authors:  Milad Ashrafizadeh; Shima Tavakol; Reza Mohammadinejad; Zahra Ahmadi; Habib Yaribeygi; Tannaz Jamialahmadi; Thomas P Johnston; Amirhossein Sahebkar
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action.

Authors:  Dongying Xu; Ping Huang; Zhaosheng Yu; Daniel H Xing; Shuai Ouyang; Guoqiang Xing
Journal:  Front Neurol       Date:  2015-01-07       Impact factor: 4.003

6.  Effect of Liuweibuqi capsules on CD4+CD25+Foxp3+ regulatory T cells, helper T cells and lung function in patients with stable chronic obstructive pulmonary disease complicated with lung Qi deficiency.

Authors:  Cheng-Yang Wang; Huan-Zhang Ding; Xiao Tang; Ze-Geng Li
Journal:  J Thorac Dis       Date:  2018-05       Impact factor: 2.895

7.  Ginseng and diabetes: the evidences from in vitro, animal and human studies.

Authors:  Hai-Dan Yuan; Jung Tae Kim; Sung Hoon Kim; Sung Hyun Chung
Journal:  J Ginseng Res       Date:  2012-01       Impact factor: 6.060

8.  Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands.

Authors:  Qin Hu; Guochun He; Jing Zhao; Anatoly Soshilov; Michael S Denison; Aiqian Zhang; Huijun Yin; Domenico Fraccalvieri; Laura Bonati; Qunhui Xie; Bin Zhao
Journal:  PLoS One       Date:  2013-06-11       Impact factor: 3.240

9.  Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice.

Authors:  Yung Choon Yoo; Junglim Lee; Seok Rae Park; Ki Yeul Nam; Young Ho Cho; Jae Eul Choi
Journal:  J Ginseng Res       Date:  2013-03       Impact factor: 6.060

Review 10.  AMP-activated protein kinase: An emerging target for ginseng.

Authors:  Kyong Ju Jeong; Go Woon Kim; Sung Hyun Chung
Journal:  J Ginseng Res       Date:  2013-12-18       Impact factor: 6.060
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