PURPOSE: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population. MATERIALS AND METHODS: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated. RESULTS: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed. CONCLUSION: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.
PURPOSE: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population. MATERIALS AND METHODS: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated. RESULTS: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed. CONCLUSION: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.
Authors: Khoschy Schawkat; Michael Ith; Andreas Christe; Wolfgang Kühn; Yojena Chittazhathu; Lauren Bains; Val Murray Runge; Johannes T Heverhagen Journal: Eur Radiol Date: 2018-01-04 Impact factor: 5.315
Authors: Jonathan T Elliott; Kimberley S Samkoe; Jason R Gunn; Errol E Stewart; Timothy B Gardner; Kenneth M Tichauer; Ting-Yim Lee; P Jack Hoopes; Stephen P Pereira; Tayyaba Hasan; Brian W Pogue Journal: Acad Radiol Date: 2015-02-14 Impact factor: 3.173
Authors: Matthew S Adams; Serena J Scott; Vasant A Salgaonkar; Graham Sommer; Chris J Diederich Journal: Int J Hyperthermia Date: 2016-01-21 Impact factor: 3.914
Authors: S Y Lim; K Nakamura; K Morishita; N Sasaki; M Murakami; T Osuga; N Yokoyama; H Ohta; M Yamasaki; M Takiguchi Journal: J Vet Intern Med Date: 2014-09-30 Impact factor: 3.333
Authors: Rocio Garcia-Carbonero; Roberto Garcia-Figueiras; Alberto Carmona-Bayonas; Isabel Sevilla; Alex Teule; Maria Quindos; Enrique Grande; Jaume Capdevila; Javier Aller; Javier Arbizu; Paula Jimenez-Fonseca Journal: Cancer Metastasis Rev Date: 2015-12 Impact factor: 9.264
Authors: Rie Ø Eriksen; Louise S Strauch; Michael Sandgaard; Thomas S Kristensen; Michael B Nielsen; Carsten A Lauridsen Journal: Diagnostics (Basel) Date: 2016-09-06