Literature DB >> 21810433

Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.

Kiersten S Smith1, Uwe Rudolph.   

Abstract

GABA(A) receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA(A) receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA(A) receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA(A) receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21810433      PMCID： PMC3340889          DOI： 10.1016/j.neuropharm.2011.07.026

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  66 in total

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  36 in total

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Review 4.  Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?

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6.  Metformin produces anxiolytic-like effects in rats by facilitating GABAA receptor trafficking to membrane.

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9.  Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress.

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10.  Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.

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