H Chen1, L Zhou, L Meng, M Liu, J Tan, L Gao, J Zhang. 1. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang Road 107, Guangdong, Guangzhou, China.
Abstract
AIM: The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy. METHODS:One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured. RESULTS:Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased. CONCLUSION:Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
RCT Entities:
AIM: The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy. METHODS: One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured. RESULTS: Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased. CONCLUSION: Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
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