Literature DB >> 21807513

Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages.

Jun Li1, Chun-Ru Liao, Jun-Qi Wei, Li-Xia Chen, Feng Zhao, Feng Qiu.   

Abstract

Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC(50) values of 3.13, 2.81 and 2.41 μM, respectively.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21807513     DOI： 10.1016/j.bmcl.2011.07.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Diarylheptanoids from Dioscorea villosa (Wild Yam).

Authors:  Shi-Hui Dong; Dejan Nikolić; Charlotte Simmler; Feng Qiu; Richard B van Breemen; Djaja D Soejarto; Guido F Pauli; Shao-Nong Chen
Journal:  J Nat Prod       Date:  2012-12-17       Impact factor: 4.050

2.  Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa.

Authors:  Takahiro Matsumoto; Seikou Nakamura; Katsuyoshi Fujimoto; Tomoe Ohta; Keiko Ogawa; Masayuki Yoshikawa; Eri Onishi; Masashi Fukaya; Hisashi Matsuda
Journal:  J Nat Med       Date:  2014-10-10       Impact factor: 2.343

Review 3.  Two Traditional Chinese Medicines Curcumae Radix and Curcumae Rhizoma: An Ethnopharmacology, Phytochemistry, and Pharmacology Review.

Authors:  Yang Zhou; Meng Xie; Yan Song; Wenping Wang; Haoran Zhao; Yuxin Tian; Yan Wang; Shaojuan Bai; Yichen Zhao; Xiaoyi Chen; Gaimei She
Journal:  Evid Based Complement Alternat Med       Date:  2016-02-18       Impact factor: 2.629

4.  Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS.

Authors:  Zhenwei Lan; Ying Zhang; Yue Sun; Lvhong Wang; Yuting Huang; Hui Cao; Shumei Wang; Jiang Meng
Journal:  Front Pharmacol       Date:  2021-12-10       Impact factor: 5.810
  4 in total

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