| Literature DB >> 21807472 |
Fabio Temussi1, Flavio Cermola, Marina Dellagreca, M Rosaria Iesce, Monica Passananti, Lucio Previtera, Armando Zarrelli.
Abstract
Photochemical behaviour of indomethacin in aqueous media at 254nm, 310nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur.Entities:
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Year: 2011 PMID： 21807472 DOI： 10.1016/j.jpba.2011.07.005
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935