Literature DB >> 21807421

Digoxin - time to take the gloves off?

Emma Eade1, Rebecca Cooper, Andrew R J Mitchell.   

Abstract

Digoxin has been used for hundreds of years to aid rate control in atrial fibrillation and as a positive inotrope in heart failure. Our familiarity with digoxin has allowed it to become easily prescribed even though there are data suggesting that use of digoxin may in fact result in increased mortality and pro-arrhythmia. Within this review we explain some of the outcome data associated with digoxin use to determine if it is time to take the gloves off and examine if we should still be using this drug in the 21st century.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID: 21807421     DOI: 10.1016/j.ijcard.2011.07.034

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN: 0167-5273            Impact factor:   4.164


  3 in total

1.  Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling.

Authors:  Hong Wei; Djahida Bedja; Norimichi Koitabashi; Dongmei Xing; Jasper Chen; Karen Fox-Talbot; Rosanne Rouf; Shaoping Chen; Charles Steenbergen; John W Harmon; Harry C Dietz; Kathleen L Gabrielson; David A Kass; Gregg L Semenza
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-08       Impact factor: 11.205

Review 2.  REV-ERB and ROR nuclear receptors as drug targets.

Authors:  Douglas J Kojetin; Thomas P Burris
Journal:  Nat Rev Drug Discov       Date:  2014-03       Impact factor: 84.694

Review 3.  Hypoxia-inducible factor 1 and cardiovascular disease.

Authors:  Gregg L Semenza
Journal:  Annu Rev Physiol       Date:  2013-08-21       Impact factor: 19.318

  3 in total

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