Literature DB >> 2180739

Aging and the response to Salmonella infection.

S F Bradley1, C A Kauffman.   

Abstract

We investigated the effect of age on the ability of Fischer 344 rats to mount a febrile response and contain infection due to Salmonella typhimurium. Elderly (22-23 month), middle-aged (12-13 month) and young (2-3 month) rats were inoculated intraperitoneally with 1.5 X 10(6) organisms and the febrile response and liver and spleen bacterial counts were followed for 13 days. The elderly had a more sluggish febrile response and did not achieve as great a maximum temperature elevation as the young and middle-aged rats. Except for days 1 and 5, bacterial counts in liver and spleen were greater in the elderly rats than in young and middle-aged rats.

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Year:  1990        PMID： 2180739     DOI： 10.1016/0531-5565(90)90012-q

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  12 in total

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