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Literature DB >> 2180733

The effects of bFGF, IGF-I, and TGF-beta on RMo skeletal muscle cell proliferation and differentiation.

Abstract

A new skeletal muscle cell line, rat myoblast omega or RMo, has been characterized with regard to the effects of three growth factors: basic fibroblast growth factor (bFGF), insulin-like growth factor I (IGF-I), and transforming growth factor beta (TGF-beta). Results indicate a differential response of these factors on both cell proliferation and differentiation. Exposure to bFGF and IGF-I stimulate proliferation, while TGF-beta has no effect on cell number. RMo cell differentiation, as indicated by skeletal myosin synthesis, is enhanced by IGF-I, whereas both bFGF and TGF-beta suppress differentiation. These responses are in agreement with the effects of bFGF, IGF-I, and TGF-beta on myogenic cells cultured from fetal and postnatal muscle, thereby suggesting that RMo cells can serve as a model system for the study of growth factor effects on skeletal muscle cells.

Entities: Gene Species

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Year: 1990 PMID： 2180733 DOI： 10.1016/0014-4827(90)90088-r

Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905

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Cited

11 in total

1. NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.

Authors: Jason M Dahlman; Nadine Bakkar; Wei He; Denis C Guttridge
Journal: J Biol Chem Date: 2009-12-14 Impact factor: 5.157

2. Identification of differentially regulated secretome components during skeletal myogenesis.

Authors: C Y X'avia Chan; Olena Masui; Olga Krakovska; Vladimir E Belozerov; Sebastien Voisin; Shaun Ghanny; Jian Chen; Dharsee Moyez; Peihong Zhu; Kenneth R Evans; John C McDermott; K W Michael Siu
Journal: Mol Cell Proteomics Date: 2011-02-22 Impact factor: 5.911

3. Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.

Authors: Dustin T Yates; Derek S Clarke; Antoni R Macko; Miranda J Anderson; Leslie A Shelton; Marie Nearing; Ronald E Allen; Robert P Rhoads; Sean W Limesand
Journal: J Physiol Date: 2014-05-23 Impact factor: 5.182

Review 4. Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.

Authors: Ronald W Matheny; Bradley C Nindl; Martin L Adamo
Journal: Endocrinology Date: 2010-02-03 Impact factor: 4.736

5. Primary myoblasts from intrauterine growth-restricted fetal sheep exhibit intrinsic dysfunction of proliferation and differentiation that coincides with enrichment of inflammatory cytokine signaling pathways.

Authors: Robert J Posont; Micah S Most; Caitlin N Cadaret; Eileen S Marks-Nelson; Kristin A Beede; Sean W Limesand; Ty B Schmidt; Jessica L Petersen; Dustin T Yates
Journal: J Anim Sci Date: 2022-08-01 Impact factor: 3.338

The effects of bFGF, IGF-I, and TGF-beta on RMo skeletal muscle cell proliferation and differentiation.

1. NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.

2. Identification of differentially regulated secretome components during skeletal myogenesis.

3. Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres.

Review 4. Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.

5. Primary myoblasts from intrauterine growth-restricted fetal sheep exhibit intrinsic dysfunction of proliferation and differentiation that coincides with enrichment of inflammatory cytokine signaling pathways.

6. Disruptions of muscle fiber plasma membranes. Role in exercise-induced damage.

7. Determination of the histological distribution of insulin like growth factor 1 receptors in the rat gut.

8. A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration.

9. New Modulators for IGF-I Activity within IGF-I Processing Products.

10. Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor.