Literature DB >> 21806374

The University of Kansas High-Throughput Screening Laboratory. Part II: enabling collaborative drug-discovery partnerships through cutting-edge screening technology.

Peter R McDonald1, Anuradha Roy, Rathnam Chaguturu.   

Abstract

The University of Kansas High-Throughput Screening (KU HTS) core is a state-of-the-art drug-discovery facility with an entrepreneurial open-service policy, which provides centralized resources supporting public- and private-sector research initiatives. The KU HTS core was established in 2002 at the University of Kansas with support from an NIH grant and the state of Kansas. It collaborates with investigators from national and international academic, nonprofit and pharmaceutical organizations in executing HTS-ready assay development and screening of chemical libraries for target validation, probe selection, hit identification and lead optimization. This is part two of a contribution from the KU HTS laboratory.

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Year:  2011        PMID: 21806374      PMCID: PMC3167485          DOI: 10.4155/fmc.11.84

Source DB:  PubMed          Journal:  Future Med Chem        ISSN: 1756-8919            Impact factor:   3.808


  5 in total

Review 1.  Selective optimization of side activities: another way for drug discovery.

Authors:  Camille G Wermuth
Journal:  J Med Chem       Date:  2004-03-11       Impact factor: 7.446

2.  Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Authors:  James Inglese; Douglas S Auld; Ajit Jadhav; Ronald L Johnson; Anton Simeonov; Adam Yasgar; Wei Zheng; Christopher P Austin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-24       Impact factor: 11.205

3.  Applications of adaptive focused acoustics to compound management.

Authors:  Elizabeth Nixon; Sue Holland-Crimmin; Brian Lupotsky; James Chan; Jon Curtis; Karen Dobbs; Zoe Blaxill
Journal:  J Biomol Screen       Date:  2009-06-01

4.  K-Screen: a free application for high throughput screening data analysis, visualization, and laboratory information management.

Authors:  David Tai; Rathnam Chaguturu; Jianwen Fang
Journal:  Comb Chem High Throughput Screen       Date:  2011-11       Impact factor: 1.339

5.  The University of Kansas High-Throughput Screening laboratory. Part I: meeting drug-discovery needs in the heartland of America with entrepreneurial flair.

Authors:  Peter R McDonald; Anuradha Roy; Rathnam Chaguturu
Journal:  Future Med Chem       Date:  2011-05       Impact factor: 3.808

  5 in total
  1 in total

1.  A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.

Authors:  Jayme L Dahlin; Rondedrick Sinville; Jonathan Solberg; Hui Zhou; Junhong Han; Subhashree Francis; Jessica M Strasser; Kristen John; Derek J Hook; Michael A Walters; Zhiguo Zhang
Journal:  PLoS One       Date:  2013-11-18       Impact factor: 3.240

  1 in total

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