Dan Yang1, Xianbao Liu, Meixiang Xiang. 1. Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Abstract
OBJECTIVE: The aim of the study was to explore the relationship between lipids ratio and the degree of coronary artery stenosis. METHODS: According to the Gensini score of inpatients in the Cardiology Department of the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China, from January 2008 to June 2010, a total of 207 patients (group 1: control group = 34 patients; group 2: 1-30 score group = 84 patients; group 3: 31-90 score group = 66 patients; and group 4: >90 score group = 23 patients) were enrolled, and the relationship between lipids and the degree of coronary artery stenosis was determined. RESULTS: Our study showed that the severity of coronary lesions was increased with the elevation of low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), LDL-C, triglycerides (TG), TC/HDL-C, TG/HDL-C and reduction of HDL-C. Compared with group 1, LDL-C/HDL-C, TC/HDL-C were significantly increased in groups 2, 3 and 4 (p < 0.05), and compared with group 2, LDL-C/HDL-C, TC/HDL-C in groups 3 and 4 were significantly increased (p < 0.05). There were no differences in the value of TG, TG/HDL-C among groups 2, 3 and 4 (p > 0.05). Furthermore, the Pearson correlation analysis revealed that LDL-C/HDL-C (r = 0.54, p < 0.05) and TC/HDL-C (r = 0.50, p < 0.05) were significantly and positively correlated with the coronary artery lesions. CONCLUSIONS: The results suggested that the severity of coronary artery lesions were correlated with abnormal lipid metabolism, and LDL-C/HDL-C, TC/HDL-C are better indicators than other measures. However, the predictive value of TG/HDL-C needs further study. Received for publication 25 October 2010; accepted for publication 14 April 2011.
OBJECTIVE: The aim of the study was to explore the relationship between lipids ratio and the degree of coronary artery stenosis. METHODS: According to the Gensini score of inpatients in the Cardiology Department of the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China, from January 2008 to June 2010, a total of 207 patients (group 1: control group = 34 patients; group 2: 1-30 score group = 84 patients; group 3: 31-90 score group = 66 patients; and group 4: >90 score group = 23 patients) were enrolled, and the relationship between lipids and the degree of coronary artery stenosis was determined. RESULTS: Our study showed that the severity of coronary lesions was increased with the elevation of low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), LDL-C, triglycerides (TG), TC/HDL-C, TG/HDL-C and reduction of HDL-C. Compared with group 1, LDL-C/HDL-C, TC/HDL-C were significantly increased in groups 2, 3 and 4 (p < 0.05), and compared with group 2, LDL-C/HDL-C, TC/HDL-C in groups 3 and 4 were significantly increased (p < 0.05). There were no differences in the value of TG, TG/HDL-C among groups 2, 3 and 4 (p > 0.05). Furthermore, the Pearson correlation analysis revealed that LDL-C/HDL-C (r = 0.54, p < 0.05) and TC/HDL-C (r = 0.50, p < 0.05) were significantly and positively correlated with the coronary artery lesions. CONCLUSIONS: The results suggested that the severity of coronary artery lesions were correlated with abnormal lipid metabolism, and LDL-C/HDL-C, TC/HDL-C are better indicators than other measures. However, the predictive value of TG/HDL-C needs further study. Received for publication 25 October 2010; accepted for publication 14 April 2011.
Authors: V Manninen; L Tenkanen; P Koskinen; J K Huttunen; M Mänttäri; O P Heinonen; M H Frick Journal: Circulation Date: 1992-01 Impact factor: 29.690
Authors: A R Sharrett; C M Ballantyne; S A Coady; G Heiss; P D Sorlie; D Catellier; W Patsch Journal: Circulation Date: 2001-09-04 Impact factor: 29.690
Authors: D J Gordon; J L Probstfield; R J Garrison; J D Neaton; W P Castelli; J D Knoke; D R Jacobs; S Bangdiwala; H A Tyroler Journal: Circulation Date: 1989-01 Impact factor: 29.690