| Literature DB >> 21805972 |
Yuji Ito1, Kazunori Takahashi, Hiromasa Nagase, Toshio Honda.
Abstract
A novel synthetic path to sequosempervirin A was established by employing a samarium diiodide promoted intramolecular Barbier-type reaction of the lactonic iodide, in which the key structural feature, a spiro[4.5]decane ring system, could be constructed by controlling the stereochemistry of the hydroxyl group at the 8-position. The absolute configuration of natural sequosempervirin A was revised to be 4S based on this synthesis.Entities:
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Year: 2011 PMID： 21805972 DOI： 10.1021/ol2018533
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005