Literature DB >> 21805502

Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts.

Roman Ashauer1, Annika Agatz, Carlo Albert, Virginie Ducrot, Nika Galic, Jan Hendriks, Tjalling Jager, Andreas Kretschmann, Isabel O'Connor, Mascha Nadine Rubach, Anna-Maija Nyman, Walter Schmitt, Julita Stadnicka, Paul J van den Brink, Thomas G Preuss.   

Abstract

We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined.
Copyright © 2011 SETAC.

Mesh：

Year:  2011        PMID： 21805502     DOI： 10.1002/etc.639

Source DB:  PubMed          Journal:  Environ Toxicol Chem        ISSN： 0730-7268            Impact factor:   3.742


  13 in total

1.  Reconsidering sufficient and optimal test design in acute toxicity testing.

Authors:  Tjalling Jager
Journal:  Ecotoxicology       Date:  2013-11-07       Impact factor: 2.823

2.  Toward sustainable environmental quality: Priority research questions for Europe.

Authors:  Paul J Van den Brink; Alistair B A Boxall; Lorraine Maltby; Bryan W Brooks; Murray A Rudd; Thomas Backhaus; David Spurgeon; Violaine Verougstraete; Charmaine Ajao; Gerald T Ankley; Sabine E Apitz; Kathryn Arnold; Tomas Brodin; Miguel Cañedo-Argüelles; Jennifer Chapman; Jone Corrales; Marie-Agnès Coutellec; Teresa F Fernandes; Jerker Fick; Alex T Ford; Gemma Giménez Papiol; Ksenia J Groh; Thomas H Hutchinson; Hank Kruger; Jussi V K Kukkonen; Stefania Loutseti; Stuart Marshall; Derek Muir; Manuel E Ortiz-Santaliestra; Kai B Paul; Andreu Rico; Ismael Rodea-Palomares; Jörg Römbke; Tomas Rydberg; Helmut Segner; Mathijs Smit; Cornelis A M van Gestel; Marco Vighi; Inge Werner; Elke I Zimmer; Joke van Wensem
Journal:  Environ Toxicol Chem       Date:  2018-07-19       Impact factor: 3.742

3.  Extrapolating ecotoxicological effects from individuals to populations: a generic approach based on Dynamic Energy Budget theory and individual-based modeling.

Authors:  Benjamin T Martin; Tjalling Jager; Roger M Nisbet; Thomas G Preuss; Monika Hammers-Wirtz; Volker Grimm
Journal:  Ecotoxicology       Date:  2013-02-22       Impact factor: 2.823

4.  The ChimERA project: coupling mechanistic exposure and effect models into an integrated platform for ecological risk assessment.

Authors:  F De Laender; Paul J van den Brink; Colin R Janssen; Antonio Di Guardo
Journal:  Environ Sci Pollut Res Int       Date:  2014-02-16       Impact factor: 4.223

5.  Environmental risk assessment of fluctuating diazinon concentrations in an urban and agricultural catchment using toxicokinetic-toxicodynamic modeling.

Authors:  Roman Ashauer; Irene Wittmer; Christian Stamm; Beate I Escher
Journal:  Environ Sci Technol       Date:  2011-10-19       Impact factor: 9.028

6.  Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment.

Authors:  Cheryl A Murphy; Roger M Nisbet; Philipp Antczak; Natàlia Garcia-Reyero; Andre Gergs; Konstadia Lika; Teresa Mathews; Erik B Muller; Diane Nacci; Angela Peace; Christopher H Remien; Irvin R Schultz; Louise M Stevenson; Karen H Watanabe
Journal:  Integr Environ Assess Manag       Date:  2018-06-30       Impact factor: 3.084

7.  An individual-based model of zebrafish population dynamics accounting for energy dynamics.

Authors:  Rémy Beaudouin; Benoit Goussen; Benjamin Piccini; Starrlight Augustine; James Devillers; François Brion; Alexandre R R Péry
Journal:  PLoS One       Date:  2015-05-04       Impact factor: 3.240

Review 8.  Influence of exposure and toxicokinetics on measures of aquatic toxicity for organic contaminants: a case study review.

Authors:  Peter F Landrum; Peter M Chapman; Jerry Neff; David S Page
Journal:  Integr Environ Assess Manag       Date:  2013-02-20       Impact factor: 2.992

9.  A method to predict and understand fish survival under dynamic chemical stress using standard ecotoxicity data.

Authors:  Roman Ashauer; Pernille Thorbek; Jacqui S Warinton; James R Wheeler; Steve Maund
Journal:  Environ Toxicol Chem       Date:  2013-03-04       Impact factor: 3.742

Review 10.  The pros and cons of ecological risk assessment based on data from different levels of biological organization.

Authors:  Jason R Rohr; Christopher J Salice; Roger M Nisbet
Journal:  Crit Rev Toxicol       Date:  2016-06-24       Impact factor: 6.184
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