Literature DB >> 21805440

Protein C inhibitor.

Joost C M Meijers1, Heiko Herwald.   

Abstract

Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility. The biological function of PCI is unknown due to broad enzyme specificity, its wide tissue distribution, and the lack of a suitable animal model. This review highlights the specific roles of PCI in the areas of hemostasis and thrombosis and fertilization, and it also describes the latest information on the fascinating participation of the protein in intracellular processes, phospholipid binding, and killing of bacteria. © Thieme Medical Publishers.

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Year:  2011        PMID： 21805440     DOI： 10.1055/s-0031-1276583

Source DB:  PubMed          Journal:  Semin Thromb Hemost        ISSN： 0094-6176            Impact factor:   4.180


  9 in total

1.  Circulating activated protein C in thrombophilia carriers.

Authors:  Thijs E van Mens; Joost C M Meijers; Saskia Middeldorp
Journal:  J Thromb Thrombolysis       Date:  2017-04       Impact factor: 2.300

2.  Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.

Authors:  Alice J Sigurdson; Alina V Brenner; James A Roach; Lilia Goudeva; Jörg A Müller; Kai Nerlich; Christoph Reiners; Robert Schwab; Liliane Pfeiffer; Melanie Waldenberger; Melissa Braganza; Li Xu; Erich M Sturgis; Meredith Yeager; Stephen J Chanock; Ruth M Pfeiffer; Michael Abend; Matthias Port
Journal:  Carcinogenesis       Date:  2016-04-28       Impact factor: 4.944

3.  High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.

Authors:  Junru Wu; Hamed Moheimani; Shimena Li; Upendra K Kar; Jillian Bonaroti; Richard S Miller; Brian J Daley; Brian G Harbrecht; Jeffrey A Claridge; Danielle S Gruen; Herbert A Phelan; Francis X Guyette; Matthew D Neal; Jishnu Das; Jason L Sperry; Timothy R Billiar
Journal:  Ann Surg       Date:  2022-07-19       Impact factor: 13.787

4.  A novel protein C inhibitor gene mutation in pediatric stroke patients after bone marrow transplantation.

Authors:  Didem Torun; Gülhis Deda; Mehmet Ertem; Zümrüt Uysal; Erkan Yılmaz; Nejat Akar
Journal:  Mol Biol Rep       Date:  2013-05-14       Impact factor: 2.316

5.  Modeling of human factor Va inactivation by activated protein C.

Authors:  Maria Cristina Bravo; Thomas Orfeo; Kenneth G Mann; Stephen J Everse
Journal:  BMC Syst Biol       Date:  2012-05-20

Review 6.  Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis.

Authors:  Steven P Grover; Nigel Mackman
Journal:  Front Cardiovasc Med       Date:  2022-05-03

7.  Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer.

Authors:  Alina V Brenner; Gila Neta; Erich M Sturgis; Ruth M Pfeiffer; Amy Hutchinson; Meredith Yeager; Li Xu; Cindy Zhou; William Wheeler; Margaret A Tucker; Stephen J Chanock; Alice J Sigurdson
Journal:  PLoS One       Date:  2013-03-08       Impact factor: 3.240

8.  A+-helix of protein C inhibitor (PCI) is a cell-penetrating peptide that mediates cell membrane permeation of PCI.

Authors:  Hanjiang Yang; Felix Christof Wahlmüller; Bettina Sarg; Margareta Furtmüller; Margarethe Geiger
Journal:  J Biol Chem       Date:  2014-12-08       Impact factor: 5.157

9.  Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis.

Authors:  Chen Zou; Changjing Han; Minjie Zhao; Jingjing Yu; Lin Bai; Yuan Yao; Shuaixin Gao; Hui Cao; Zhi Zheng
Journal:  Clin Proteomics       Date:  2018-03-09       Impact factor: 3.988
  9 in total

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