Literature DB >> 21805349

The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in rheumatologic disorders: a comprehensive review.

Christos G Mihos1, Rosa T Artola, Orlando Santana.   

Abstract

The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment for hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes, including a wide range of rheumatologic disorders. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropic effects of statins in rheumatologic disorders and emphasizes the importance of randomized, placebo-controlled trials to further elucidate this interesting phenomenon.

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Year:  2011        PMID： 21805349     DOI： 10.1007/s00296-011-2008-6

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  90 in total

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Journal:  Circ Res       Date:  2006-01-05       Impact factor: 17.367

2.  Behçet's disease complicated by IgA nephropathy with nephrotic syndrome.

Authors:  Tatsuo Hashimoto; Yoshiyuki Toya; Minoru Kihara; Machiko Yabana; Yoshiaki Inayama; Ken-Ichiro Tanaka; Kousaku Iwatsubo; Mai Yanagi; Jin Oshikawa; Toshiharu Kokuho; Tadashi Kuji; Shin-Ichiro Yoshida; Kouichi Tamura; Satoshi Umemura
Journal:  Clin Exp Nephrol       Date:  2008-01-26       Impact factor: 2.801

3.  Effects of atorvastatin and lisinopril on endothelial dysfunction in patients with Behçet's disease.

Authors:  Mehmet Tugrul Inanc; Nihat Kalay; Turgun Heyit; Ibrahim Ozdogru; Mehmet Gungor Kaya; Ali Dogan; Mustafa Duran; Haci Ahmet Kasapkara; Ozgur Gunebakmaz; Murat Borlu; Mikail Yarlıoglues; Abdurrahman Oguzhan
Journal:  Echocardiography       Date:  2010-09       Impact factor: 1.724

4.  Statins have additive effects to vertebral bone mineral density in combination with risedronate in hypercholesterolemic postmenopausal women.

Authors:  Hamit Alper Tanriverdi; Aykut Barut; Selda Sarikaya
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2005-05-01       Impact factor: 2.435

5.  Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia.

Authors:  M H Chan; T W Mak; R W Chiu; C C Chow; I H Chan; C W Lam
Journal:  J Clin Endocrinol Metab       Date:  2001-09       Impact factor: 5.958

6.  Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway.

Authors:  Pei-Yu Chen; Jui-Sheng Sun; Yang-Hwei Tsuang; Ming-Hong Chen; Pei-Wei Weng; Feng-Huei Lin
Journal:  Nutr Res       Date:  2010-03       Impact factor: 3.315

7.  Hyperlipidaemia, statin use and the risk of developing rheumatoid arthritis.

Authors:  S S Jick; H Choi; L Li; I B McInnes; N Sattar
Journal:  Ann Rheum Dis       Date:  2008-07-28       Impact factor: 19.103

8.  Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort.

Authors:  Hiroshi Okamoto; Kyoko Koizumi; Shigeo Kamitsuji; Eisuke Inoue; Masako Hara; Taisuke Tomatsu; Naoyuki Kamatani; Hisashi Yamanaka
Journal:  J Rheumatol       Date:  2007-04-15       Impact factor: 4.666

9.  Atorvastatin therapy improves endothelial-dependent vasodilation in patients with systemic lupus erythematosus: an 8 weeks controlled trial.

Authors:  G A Ferreira; T P Navarro; R W Telles; L E C Andrade; E I Sato
Journal:  Rheumatology (Oxford)       Date:  2007-08-10       Impact factor: 7.580

10.  Atorvastatin and BMD in coronary syndrome. Role of Lys656Asn polymorphism of leptin receptor gene.

Authors:  José Luis Pérez-Castrillón; Gemma Vega; Laura Abad; Alberto Sanz-Cantalapiedra; Manuel Gonzalez Sagredo; Daniel De Luis; Antonio Duenas-Laita
Journal:  Endocr J       Date:  2008-11-20       Impact factor: 2.349
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  11 in total

1.  Incidental findings on chest computed tomography are common and linked to inflammation in HIV-infected adults.

Authors:  Michelle S Park; Corrilynn O Hileman; Abdus Sattar; Robert Gilkeson; Grace A McComsey
Journal:  Antivir Ther       Date:  2016-09-24

2.  The Effect of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases.

Authors:  April M Jorge; Na Lu; Sarah F Keller; Sharan K Rai; Yuqing Zhang; Hyon K Choi
Journal:  J Rheumatol       Date:  2018-09-01       Impact factor: 4.666

3.  Revisiting secondary amyloidosis for an inadequately investigated feature: dyslipidemia.

Authors:  Serhan Piskinpasa; Hadim Akoglu; Eyup Koc; Fatma Dogru; Ezgi Yenigun Coskun; Didem Turgut; Nihal Ozkayar; Ramazan Ozturk; Ali Riza Odabas; Fatih Dede
Journal:  Rheumatol Int       Date:  2012-07-31       Impact factor: 2.631

4.  Use of rosuvastatin in HIV-associated chronic obstructive pulmonary disease.

Authors:  Alison Morris; Meghan Fitzpatrick; Marnie Bertolet; Shulin Qin; Lawrence Kingsley; Nicolas Leo; Cathy Kessinger; Heather Michael; Deborah Mcmahon; Renee Weinman; Stephen Stone; Joseph K Leader; Eric Kleerup; Laurence Huang; Stephen R Wisniewski
Journal:  AIDS       Date:  2017-02-20       Impact factor: 4.177

5.  Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling.

Authors:  Elena N Atochina-Vasserman; Dmitry A Goncharov; Alla V Volgina; Megan Milavec; Melane L James; Vera P Krymskaya
Journal:  Am J Respir Cell Mol Biol       Date:  2013-11       Impact factor: 6.914

6.  Beyond lipid lowering: pleiotropic effects of statins in heart failure.

Authors:  C A Swenne
Journal:  Neth Heart J       Date:  2013-09       Impact factor: 2.380

7.  Herpes zoster is associated with prior statin use: a population-based case-control study.

Authors:  Shiu-Dong Chung; Ming-Chieh Tsai; Shih-Ping Liu; Herng-Ching Lin; Jiunn-Horng Kang
Journal:  PLoS One       Date:  2014-10-24       Impact factor: 3.240

8.  Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel.

Authors:  Maciej Banach; Manfredi Rizzo; Peter P Toth; Michel Farnier; Michael H Davidson; Khalid Al-Rasadi; Wilbert S Aronow; Vasilis Athyros; Dragan M Djuric; Marat V Ezhov; Robert S Greenfield; G Kees Hovingh; Karam Kostner; Corina Serban; Daniel Lighezan; Zlatko Fras; Patrick M Moriarty; Paul Muntner; Assen Goudev; Richard Ceska; Stephen J Nicholls; Marlena Broncel; Dragana Nikolic; Daniel Pella; Raman Puri; Jacek Rysz; Nathan D Wong; Laszlo Bajnok; Steven R Jones; Kausik K Ray; Dimitri P Mikhailidis
Journal:  Arch Med Sci       Date:  2015-03-14       Impact factor: 3.318

Review 9.  Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials.

Authors:  Alexios S Antonopoulos; Marios Margaritis; Regent Lee; Keith Channon; Charalambos Antoniades
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

Review 10.  The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease.

Authors:  Sabas I Gomez; Christos G Mihos; Andres M Pineda; Orlando Santana
Journal:  Int J Nephrol Renovasc Dis       Date:  2014-03-28
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