Literature DB >> 21804655

Sources of Cognitive Exploration: Genetic Variation in the Prefrontal Dopamine System Predicts Openness/Intellect.

Colin G Deyoung1, Dante Cicchetti, Fred A Rogosch, Jeremy R Gray, Maria Eastman, Elena L Grigorenko.   

Abstract

The personality trait Openness/Intellect reflects the tendency to be imaginative, curious, perceptive, artistic, and intellectual-all characteristics that involve cognitive exploration. Little is known about the biological basis of Openness/Intellect, but the trait has been linked to cognitive functions of prefrontal cortex, and the neurotransmitter dopamine plays a key role in motivation to explore. The hypothesis that dopamine is involved in Openness/Intellect was supported by examining its association with two genes that are central components of the prefrontal dopaminergic system. In two demographically different samples (children: N = 608; adults: N = 214), variation in the dopamine D4 receptor gene (DRD4) and the catechol-O-methyltransferase gene (COMT) predicted Openness/Intellect, as main effects in the child sample and in interaction in adults.

Entities:  

Year:  2011        PMID： 21804655      PMCID： PMC3143482          DOI： 10.1016/j.jrp.2011.04.002

Source DB:  PubMed          Journal:  J Res Pers        ISSN： 0092-6566


  52 in total

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9.  The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus.

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10.  The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds.

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  21 in total

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5.  The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes.

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6.  Biological and cognitive underpinnings of religious fundamentalism.

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7.  Openness to Experience and Intellect Differentially Predict Creative Achievement in the Arts and Sciences.

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8.  A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality.

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9.  Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index.

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10.  Dopa therapy and action impulsivity: subthreshold error activation and suppression in Parkinson's disease.

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