Literature DB >> 21804259

Cinchona alkaloids are also produced by an endophytic filamentous fungus living in cinchona plant.

Shoji Maehara1, Partomuan Simanjuntak, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya.   

Abstract

We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in endophytic microbe cells.

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Year:  2011        PMID： 21804259     DOI： 10.1248/cpb.59.1073

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

1.  Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce Cinchona alkaloids.

Authors:  Shoji Maehara; Partomuan Simanjuntak; Yoshihide Maetani; Chinami Kitamura; Kazuyoshi Ohashi; Hirotaka Shibuya
Journal:  J Nat Med       Date:  2012-08-11       Impact factor: 2.343

2.  Composition of the endophytic filamentous fungi associated with Cinchona ledgeriana seeds and production of Cinchona alkaloids.

Authors:  Shoji Maehara; Andria Agusta; Chinami Kitamura; Kazuyoshi Ohashi; Hirotaka Shibuya
Journal:  J Nat Med       Date:  2015-12-08       Impact factor: 2.343

3.  Unexpectedly High Beta-Diversity of Root-Associated Fungal Communities in the Bolivian Andes.

Authors:  Christopher J Barnes; Carla Maldonado; Tobias G Frøslev; Alexandre Antonelli; Nina Rønsted
Journal:  Front Microbiol       Date:  2016-08-31       Impact factor: 5.640

4.  Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya).

Authors:  Carla Maldonado; Christopher J Barnes; Claus Cornett; Else Holmfred; Steen H Hansen; Claes Persson; Alexandre Antonelli; Nina Rønsted
Journal:  Front Plant Sci       Date:  2017-03-22       Impact factor: 5.753

Review 5.  Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.

Authors:  Pragya Tiwari; Hanhong Bae
Journal:  Microorganisms       Date:  2022-02-04

Review 6.  Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes.

Authors:  Muna Ali Abdalla; Lyndy J McGaw
Journal:  Front Pharmacol       Date:  2018-05-17       Impact factor: 5.810
  6 in total

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