BACKGROUND: Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown. AIMS: To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment. METHOD: Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression. RESULTS: In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk. CONCLUSIONS: Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
BACKGROUND: Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains unknown. AIMS: To determine the association between oestrogen receptor polymorphisms and late-life depression and the modifying effect of hormone treatment. METHOD:Depression was assessed using the Mini-International Neuropsychiatric Interview, according to DSM-IV criteria and the Centre for Epidemiologic Studies - Depression Scale. The association between oestrogen receptor α and β (ER-α and ER-β) polymorphisms with severe depression was examined in 6017 community-dwelling elderly people using multivariate logistic regression. RESULTS: In women, the ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depression. The A allele of ER-β rs1256049 increased the risk of depression, but only for non-current users of hormone treatment. In men, only the ER-β rs4986938 polymorphism showed a weak association with depression risk. CONCLUSIONS: Oestrogen receptor polymorphisms are associated with severe late-life depression risk in women only.
Authors: H Tiemeier; S C E Schuit; T den Heijer; J B J van Meurs; H R van Tuijl; A Hofman; M M B Breteler; H A P Pols; A G Uitterlinden Journal: Mol Psychiatry Date: 2005-09 Impact factor: 15.992
Authors: H Maruyama; H Toji; C R Harrington; K Sasaki; Y Izumi; T Ohnuma; H Arai; M Yasuda; C Tanaka; P C Emson; S Nakamura; H Kawakami Journal: Arch Neurol Date: 2000-02
Authors: J C Lambert; J M Harris; D Mann; H Lemmon; J Coates; A Cumming; D St-Clair; C Lendon Journal: Neurosci Lett Date: 2001-06-29 Impact factor: 3.046
Authors: David M Herrington; Timothy D Howard; K Bridget Brosnihan; Donald P McDonnell; Xiaolin Li; Gregory A Hawkins; David M Reboussin; Jianfeng Xu; Siqun L Zheng; Deborah A Meyers; Eugene R Bleecker Journal: Circulation Date: 2002-04-23 Impact factor: 29.690
Authors: Jung Jin Kim; Chi Un Pae; Mi Ran Kim; Jung Ah Min; Kyung Hee Kim; Chang Uk Lee; Chul Lee; In Ho Paik Journal: Psychiatry Investig Date: 2010-08-13 Impact factor: 2.505
Authors: D V Sheehan; Y Lecrubier; K H Sheehan; P Amorim; J Janavs; E Weiller; T Hergueta; R Baker; G C Dunbar Journal: J Clin Psychiatry Date: 1998 Impact factor: 4.384
Authors: K Keyes; J Agnew-Blais; A L Roberts; A Hamilton; I De Vivo; H Ranu; K Koenen Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2015-07-14 Impact factor: 4.328
Authors: Julia K Pinsonneault; Danielle Sullivan; Wolfgang Sadee; Claudio N Soares; Elizabeth Hampson; Meir Steiner Journal: Arch Womens Ment Health Date: 2013-08-07 Impact factor: 3.633
Authors: Shareen Y El-Ibiary; Steven P Hamilton; Rebecca Abel; Carolyn A Erdman; Patricia A Robertson; Patrick R Finley Journal: Innov Clin Neurosci Date: 2013-09
Authors: Zachary S Lorsch; Yong-Hwee Eddie Loh; Immanuel Purushothaman; Deena M Walker; Eric M Parise; Marine Salery; Michael E Cahill; Georgia E Hodes; Madeline L Pfau; Hope Kronman; Peter J Hamilton; Orna Issler; Benoit Labonté; Ann E Symonds; Matthew Zucker; Tie Yuan Zhang; Michael J Meaney; Scott J Russo; Li Shen; Rosemary C Bagot; Eric J Nestler Journal: Nat Commun Date: 2018-03-16 Impact factor: 14.919