INTRODUCTION: The pathophysiology of male idiopathic osteoporosis (MIO) remains unknown. The aim of this study was to evaluate the involvement of IGF-1 in MIO, and to explore the relationships between bone mineral density and serum levels of IGF-1 and sex hormones. METHODS: Inclusion criteria were osteoporosis (T-score<-2.5 SD) and/or an osteoporotic fracture. The osteoporotic patients were included after an exhaustive work-up to exclude the principal causes of secondary osteoporosis. Serum levels of IGF-1, estradiol, testosterone, SHBG, markers of bone turnover, and bone mineral density were compared between 79 MIO and 26 healthy subjects. RESULTS: A significant reduction in serum IGF-1 was found in MIO patients (p=0.0189). This remained significant after adjustment for body mass index (BMI). A negative correlation was found between SHBG and serum IGF-1 (r=-0.231, p=0.048). SHBG levels were higher in osteoporotic patients (p=0.001). The Free Testosterone Index (FTI, total testosterone/SHBG) (p=0.002) was also lower in MIO patients. After adjustment for FTI and BMI, a significant association was observed between IGF-1 level and the presence of an osteoporotic fracture, indicating an independent effect of IGF-1 level on fracture risk. The odds ratio (OR) for fracture for each SD decrease in IGF1 level was 1.8 [CI: 1.09-2.96] (p=0.021). CONCLUSION: Our study indicates a decrease in serum IGF-1 levels in MIO. This could be either the cause or the consequence of a disturbance in sex hormone metabolism with increased SHBG serum levels.
INTRODUCTION: The pathophysiology of male idiopathic osteoporosis (MIO) remains unknown. The aim of this study was to evaluate the involvement of IGF-1 in MIO, and to explore the relationships between bone mineral density and serum levels of IGF-1 and sex hormones. METHODS: Inclusion criteria were osteoporosis (T-score<-2.5 SD) and/or an osteoporotic fracture. The osteoporoticpatients were included after an exhaustive work-up to exclude the principal causes of secondary osteoporosis. Serum levels of IGF-1, estradiol, testosterone, SHBG, markers of bone turnover, and bone mineral density were compared between 79 MIO and 26 healthy subjects. RESULTS: A significant reduction in serum IGF-1 was found in MIOpatients (p=0.0189). This remained significant after adjustment for body mass index (BMI). A negative correlation was found between SHBG and serum IGF-1 (r=-0.231, p=0.048). SHBG levels were higher in osteoporoticpatients (p=0.001). The Free Testosterone Index (FTI, total testosterone/SHBG) (p=0.002) was also lower in MIOpatients. After adjustment for FTI and BMI, a significant association was observed between IGF-1 level and the presence of an osteoporotic fracture, indicating an independent effect of IGF-1 level on fracture risk. The odds ratio (OR) for fracture for each SD decrease in IGF1 level was 1.8 [CI: 1.09-2.96] (p=0.021). CONCLUSION: Our study indicates a decrease in serum IGF-1 levels in MIO. This could be either the cause or the consequence of a disturbance in sex hormone metabolism with increased SHBG serum levels.
Authors: Hemant Kulkarni; Mark Z Kos; Jennifer Neary; Thomas D Dyer; Jack W Kent; Harald H H Göring; Shelley A Cole; Anthony G Comuzzie; Laura Almasy; Michael C Mahaney; Joanne E Curran; John Blangero; Melanie A Carless Journal: Hum Mol Genet Date: 2015-06-22 Impact factor: 6.150
Authors: Nicole M Ashpole; Jacquelyn C Herron; Patrick N Estep; Sreemathi Logan; Erik L Hodges; Andriy Yabluchanskiy; Mary Beth Humphrey; William E Sonntag Journal: Age (Dordr) Date: 2016-03-11
Authors: Nicole M Ashpole; Jacquelyn C Herron; Matthew C Mitschelen; Julie A Farley; Sreemathi Logan; Han Yan; Zoltan Ungvari; Erik L Hodges; Anna Csiszar; Yuji Ikeno; Mary Beth Humphrey; William E Sonntag Journal: J Bone Miner Res Date: 2015-09-03 Impact factor: 6.741