Literature DB >> 21802990

Hematopoietic stem and progenitor cell trafficking.

Irina B Mazo1, Steffen Massberg, Ulrich H von Andrian.   

Abstract

Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21802990      PMCID: PMC3185129          DOI: 10.1016/j.it.2011.06.011

Source DB:  PubMed          Journal:  Trends Immunol        ISSN: 1471-4906            Impact factor:   16.687


  124 in total

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Review 4.  Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.

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Journal:  Annu Rev Immunol       Date:  2005       Impact factor: 28.527

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6.  Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.

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Journal:  Blood       Date:  1998-08-01       Impact factor: 22.113

9.  Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.

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Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

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Authors:  I B Mazo; J C Gutierrez-Ramos; P S Frenette; R O Hynes; D D Wagner; U H von Andrian
Journal:  J Exp Med       Date:  1998-08-03       Impact factor: 14.307

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  76 in total

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Review 3.  TLRs control hematopoiesis during infection.

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Review 7.  Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair.

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Journal:  Stem Cell Rev Rep       Date:  2016-08       Impact factor: 5.739

8.  Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization.

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