BACKGROUND: The main morbidity associated with Henoch-Schonlein purpura (HSP) results from glomerulonephritis and associated renal symptoms; thus early and accurate diagnosis would have follow-up implications. OBJECTIVE: To determine the strength of association of IgA vascular deposition with HSP in a mostly adult and hospital-based population. METHODS: We retrospectively analyzed patients with a histologic diagnosis of cutaneous leukocytoclastic vasculitis (LCV) and corresponding direct immunofluorescence (DIF) studies between 2000 and 2010. European League Against Rheumatism criteria were used to diagnose HSP cases clinically. They are purpura or petechiae with lower limb predominance plus at least one of the following: abdominal pain, LCV or proliferative glomerulonephritis with predominant IgA deposit, arthritis/arthralgia, or proteinuria or hematuria. RESULTS: IgA positivity was significantly associated with HSP (P = .0001), and yielded sensitivity of 81% and specificity of 83%. Positive predictive value of IgA staining for HSP was 84%, and negative predictive value was 81%. No other histologic features were significantly associated with HSP. LIMITATIONS: Our sample size was relatively small and mostly an inpatient population (79%). We may have missed cases of HSP and a subset of IgA+ LCV patients who did not have clinical findings of HSP by limiting our series to only cases with DIF studies done. Certain clinical data may be incomplete since they were collected retrospectively. CONCLUSIONS: Our study confirms a strong association between IgA deposits on DIF and HSP, but also highlights a subset of HSP cases in which vascular IgA deposition in the skin appears to be negative.
BACKGROUND: The main morbidity associated with Henoch-Schonlein purpura (HSP) results from glomerulonephritis and associated renal symptoms; thus early and accurate diagnosis would have follow-up implications. OBJECTIVE: To determine the strength of association of IgA vascular deposition with HSP in a mostly adult and hospital-based population. METHODS: We retrospectively analyzed patients with a histologic diagnosis of cutaneous leukocytoclastic vasculitis (LCV) and corresponding direct immunofluorescence (DIF) studies between 2000 and 2010. European League Against Rheumatism criteria were used to diagnose HSP cases clinically. They are purpura or petechiae with lower limb predominance plus at least one of the following: abdominal pain, LCV or proliferative glomerulonephritis with predominant IgA deposit, arthritis/arthralgia, or proteinuria or hematuria. RESULTS: IgA positivity was significantly associated with HSP (P = .0001), and yielded sensitivity of 81% and specificity of 83%. Positive predictive value of IgA staining for HSP was 84%, and negative predictive value was 81%. No other histologic features were significantly associated with HSP. LIMITATIONS: Our sample size was relatively small and mostly an inpatient population (79%). We may have missed cases of HSP and a subset of IgA+ LCV patients who did not have clinical findings of HSP by limiting our series to only cases with DIF studies done. Certain clinical data may be incomplete since they were collected retrospectively. CONCLUSIONS: Our study confirms a strong association between IgA deposits on DIF and HSP, but also highlights a subset of HSP cases in which vascular IgA deposition in the skin appears to be negative.
Authors: Caroline Maris Takatu; Antonio Pedro Ribeiro Heringer; Valéria Aoki; Neusa Yuriko Sakai Valente; Paula Cristina de Faria Sanchez; Jozélio Freire de Carvalho; Paulo Ricardo Criado Journal: Immunol Res Date: 2017-02 Impact factor: 2.829