Literature DB >> 21797269

A domino Michael/Dieckmann process as an entry to α-(hydroxymethyl)glutamic acid.

Carlos Aydillo1, Gonzalo Jiménez-Osés, Alberto Avenoza, Jesús H Busto, Jesús M Peregrina, María M Zurbano.   

Abstract

A domino process that involves a Michael-type addition followed by a Dieckmann reaction mediated by the participation of the cyclic carbamate group is the key step in the synthesis of both enantiomers of α-(hydroxymethyl)glutamic acid (HMG).

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Year:  2011        PMID: 21797269     DOI: 10.1021/jo201067n

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  1 in total

1.  Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG).

Authors:  Hiromasa Yoshioka; Masato Oikawa
Journal:  Springerplus       Date:  2015-11-24
  1 in total

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