Literature DB >> 21796752

A "diels-alderase" at last.

Craig A Townsend1.   

Abstract

Diels this Alder your thinking? Electrocyclization reactions are exceedingly rare in metabolic pathways. Why is this so? Recently a [4+2] cycloaddition catalyzed by a monofunctional "Diels-Alderase" has been characterized. How does a 500-fold rate enhancement shown by this enzyme stack up?
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21796752     DOI： 10.1002/cbic.201100431

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  10 in total

Review 1.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

Review 2.  Current developments and challenges in the search for a naturally selected Diels-Alderase.

Authors:  Hak Joong Kim; Mark W Ruszczycky; Hung-wen Liu
Journal:  Curr Opin Chem Biol       Date:  2012-01-17       Impact factor: 8.822

3.  An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.

Authors:  Zhenhua Tian; Peng Sun; Yan Yan; Zhuhua Wu; Qingfei Zheng; Shuaixiang Zhou; Hua Zhang; Futao Yu; Xinying Jia; Dandan Chen; Attila Mándi; Tibor Kurtán; Wen Liu
Journal:  Nat Chem Biol       Date:  2015-03-02       Impact factor: 15.040

4.  Natural Diels-Alderases: Elusive and Irresistable.

Authors:  Kimberly Klas; Sachiko Tsukamoto; David H Sherman; Robert M Williams
Journal:  J Org Chem       Date:  2015-12-04       Impact factor: 4.354

5.  Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis.

Authors:  Daniel J Sprague; Benjamin M Nugent; Ryan A Yoder; Brandon A Vara; Jeffrey N Johnston
Journal:  Org Lett       Date:  2015-01-31       Impact factor: 6.005

6.  Computational study of a model system of enzyme-mediated [4+2] cycloaddition reaction.

Authors:  Evgeniy G Gordeev; Valentine P Ananikov
Journal:  PLoS One       Date:  2015-04-08       Impact factor: 3.240

7.  Computational Insights into an Enzyme-Catalyzed [4+2] Cycloaddition.

Authors:  Yiying Zheng; Walter Thiel
Journal:  J Org Chem       Date:  2017-11-29       Impact factor: 4.354

8.  Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri.

Authors:  Alice M Banks; Lijiang Song; Gregory L Challis; Andy M Bailey; Gary D Foster
Journal:  PLoS One       Date:  2020-04-06       Impact factor: 3.240

Review 9.  Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Authors:  Andrew Currin; Neil Swainston; Philip J Day; Douglas B Kell
Journal:  Chem Soc Rev       Date:  2015-03-07       Impact factor: 54.564

10.  Biosynthesis of Grandione: An Example of Tandem Hetero Diels-Alder/Retro-Claisen Rearrangement Reaction?

Authors:  Ramiro F Quijano-Quiñones; Carolina S Castro-Segura; Gonzalo J Mena-Rejón; Mariana Quesadas-Rojas; David Cáceres-Castillo
Journal:  Molecules       Date:  2018-09-30       Impact factor: 4.411
  10 in total

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