| Literature DB >> 21794955 |
Vinko Palada1, Janoš Terzić, Joseph Mazzulli, Grace Bwala, Johann Hagenah, Borut Peterlin, Albert Y Hung, Christine Klein, Dimitri Krainc.
Abstract
Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ(2) = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD. Copyright ÂEntities:
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Year: 2011 PMID： 21794955 DOI： 10.1016/j.neurobiolaging.2011.06.015
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673