| Literature DB >> 21793522 |
Victoria L Challinor1, Patricia Y Hayes, Paul V Bernhardt, William Kitching, Reginald P Lehmann, James J De Voss.
Abstract
The absolute stereochemistry of the steroidal saponins bethosides B and C was previously assigned as (22R,25R) on the basis of work that employed Horeau's method. Our studies of helosides A and B created doubt about both the original assignment and consequently our conclusion that relied upon it. The absolute configurations of bethosides B and C are revised to (22S,25R) following X-ray crystallographic analysis of their aglycone. Synthesis and full spectral characterization of both the 22R and 22S aglycones is reported to facilitate future stereochemical assignments in this series of saponins.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21793522 DOI： 10.1021/jo2012797
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354