BACKGROUND: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. OBJECTIVE: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. METHODS: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. RESULTS: Multivariable analysis showed that participants with high AF-ALB (>or=0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR)=2.61; CI=1.03-6.58; p=0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR=2.4; CI=0.96-6.05; p=0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR=0.31; CI=0.09-1.02; p=0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR=0.31; CI=0.10-0.97; p=0.04). Participants with high AF-ALB or high AFM1 (>or=437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR=5.88; CI=1.71-20.14; p=0.005) and (OR=5.84; CI=1.15-29.54; p=0.03) respectively. CONCLUSIONS: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.
BACKGROUND: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. OBJECTIVE: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. METHODS: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. RESULTS: Multivariable analysis showed that participants with high AF-ALB (>or=0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR)=2.61; CI=1.03-6.58; p=0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR=2.4; CI=0.96-6.05; p=0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR=0.31; CI=0.09-1.02; p=0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR=0.31; CI=0.10-0.97; p=0.04). Participants with high AF-ALB or high AFM1 (>or=437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR=5.88; CI=1.71-20.14; p=0.005) and (OR=5.84; CI=1.15-29.54; p=0.03) respectively. CONCLUSIONS: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.
Authors: J S Wang; X Shen; X He; Y R Zhu; B C Zhang; J B Wang; G S Qian; S Y Kuang; A Zarba; P A Egner; L P Jacobson; A Muñoz; K J Helzlsouer; J D Groopman; T W Kensler Journal: J Natl Cancer Inst Date: 1999-02-17 Impact factor: 13.506
Authors: P Christian; K P West; S K Khatry; J Katz; S C LeClerq; E Kimbrough-Pradhan; S M Dali; S R Shrestha Journal: J Nutr Date: 2000-11 Impact factor: 4.798
Authors: Lauren Lewis; Mary Onsongo; Henry Njapau; Helen Schurz-Rogers; George Luber; Stephanie Kieszak; Jack Nyamongo; Lorraine Backer; Abdikher Mohamud Dahiye; Ambrose Misore; Kevin DeCock; Carol Rubin Journal: Environ Health Perspect Date: 2005-12 Impact factor: 9.031
Authors: Paul C Turner; Sophie E Moore; Andrew J Hall; Andrew M Prentice; Christopher P Wild Journal: Environ Health Perspect Date: 2003-02 Impact factor: 9.031
Authors: Nicole J Mitchell; Justice Kumi; Mildred Aleser; Sarah E Elmore; Kristal A Rychlik; Katherine E Zychowski; Amelia A Romoser; Timothy D Phillips; Nii-Ayi Ankrah Journal: Am J Trop Med Hyg Date: 2014-08-18 Impact factor: 2.345
Authors: Francis A Obuseh; Pauline E Jolly; Andrzej Kulczycki; John Ehiri; John Waterbor; Renee A Desmond; Peter O Preko; Yi Jiang; Chandrika J Piyathilake Journal: J Int AIDS Soc Date: 2011-11-11 Impact factor: 5.396
Authors: Pauline E Jolly; Tomi F Akinyemiju; Megha Jha; Inmaculada Aban; Andrea Gonzalez-Falero; Dnika Joseph Journal: Toxins (Basel) Date: 2015-11-30 Impact factor: 4.546
Authors: Amal Saad-Hussein; Eman M Shahy; Weam Shaheen; Mona M Taha; Heba Mahdy-Abdallah; Khadiga S Ibrahim; Salwa F Hafez; Nevein N Fadl; Karima A El-Shamy Journal: Open Access Maced J Med Sci Date: 2016-04-20