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Literature DB >> 21792237

The timing of mitochondrial DNA mutations in aging.

Konstantin Khrapko.

Abstract

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21792237 PMCID： PMC3670970 DOI： 10.1038/ng.895

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

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5 in total

1. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.

Authors: Y Michikawa; F Mazzucchelli; N Bresolin; G Scarlato; G Attardi
Journal: Science Date: 1999-10-22 Impact factor: 47.728

2. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

Authors: Y Wang; Y Michikawa; C Mallidis; Y Bai; L Woodhouse; K E Yarasheski; C A Miller; V Askanas; W K Engel; S Bhasin; G Attardi
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

Review 3. Clonal expansions of mitochondrial genomes: implications for in vivo mutational spectra.

Authors: Konstantin Khrapko; Ekaterina Nekhaeva; Yevgenya Kraytsberg; Wolfram Kunz
Journal: Mutat Res Date: 2003-01-28 Impact factor: 2.433

4. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

Authors: J L Elson; D C Samuels; D M Turnbull; P F Chinnery
Journal: Am J Hum Genet Date: 2001-02-06 Impact factor: 11.025

5. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Authors: Yiping He; Jian Wu; Devin C Dressman; Christine Iacobuzio-Donahue; Sanford D Markowitz; Victor E Velculescu; Luis A Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Journal: Nature Date: 2010-03-03 Impact factor: 49.962

5 in total

13 in total

Review 1. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging.

Authors: Yizhe Tang; Sudarshana Purkayastha; Dongsheng Cai
Journal: Trends Neurosci Date: 2014-11-14 Impact factor: 13.837

2. Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.

Authors: Kaixiong Ye; Jian Lu; Fei Ma; Alon Keinan; Zhenglong Gu
Journal: Proc Natl Acad Sci U S A Date: 2014-07-07 Impact factor: 11.205

Review 3. Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.

Authors: Karen L DeBalsi; Kirsten E Hoff; William C Copeland
Journal: Ageing Res Rev Date: 2016-04-30 Impact factor: 10.895

4. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.

Authors: Laura C Greaves; Joanna L Elson; Marco Nooteboom; John P Grady; Geoffrey A Taylor; Robert W Taylor; John C Mathers; Thomas B L Kirkwood; Doug M Turnbull
Journal: PLoS Genet Date: 2012-11-15 Impact factor: 5.917

5. Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Authors: Laura C Greaves; Marco Nooteboom; Joanna L Elson; Helen A L Tuppen; Geoffrey A Taylor; Daniel M Commane; Ramesh P Arasaradnam; Konstantin Khrapko; Robert W Taylor; Thomas B L Kirkwood; John C Mathers; Douglass M Turnbull
Journal: PLoS Genet Date: 2014-09-18 Impact factor: 5.917

The timing of mitochondrial DNA mutations in aging.

1. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.

2. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

Review 3. Clonal expansions of mitochondrial genomes: implications for in vivo mutational spectra.

4. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

5. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Review 1. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging.

2. Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.

Review 3. Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.

4. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.

5. Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

6. Resolving the Enigma of the Clonal Expansion of mtDNA Deletions.

7. Premature and accelerated aging: HIV or HAART?

Review 8. Mitochondrial dysfunction in aging: Much progress but many unresolved questions.

9. Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.

10. When man got his mtDNA deletions?