Literature DB >> 21792062

Highly active antiretroviral therapy versus zidovudine for prevention of mother-to-child transmission in a programmatic setting, Botswana.

Scott Dryden-Peterson1, Oluwemimo Jayeoba, Michael D Hughes, Haruna Jibril, Koona Keapoletswe, Josephine Tlale, Taolo A Modise, Aida Asmelash, Sikhulile Moyo, Erik van Widenfelt, Joseph Makhema, Max Essex, Roger L Shapiro, Shahin Lockman.   

Abstract

Few studies have compared the programmatic effectiveness of the recommended strategies of antenatal highly active antiretroviral therapy (HAART) and zidovudine for prevention of mother-to-child transmission. We prospectively followed infants (93% formula fed) whose mothers who took either HAART (258 infants) or zidovudine (170 infants) during pregnancy in the Botswana national program. Overall, 10 infants (2.5%) acquired HIV--9 infants in the zidovudine group (5.5%, 95% confidence interval: 2.6% to 10.2%) and 1 infant in the HAART group (0.4%, 95% confidence interval: 0.0% to 2.2%). Maternal HAART was associated with decreased prevention of mother-to-child transmission (P = 0.001) and improved HIV-free survival (P = 0.040) compared with zidovudine (with or without single-dose nevirapine) in a programmatic setting.

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Year:  2011        PMID： 21792062      PMCID： PMC3196679          DOI： 10.1097/QAI.0b013e31822d4063

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  15 in total

1.  Short-term evaluation of zidovudine-treated patients: decrease in plasma and cellular viraemia titres.

Authors:  C Tamalet; B Masquelier; F Ferchal; H Agut; J Puel; F Brun-Vézinet; H Fleury; C Rouzioux
Journal:  AIDS       Date:  1992-11       Impact factor: 4.177

2.  Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.

Authors:  R S Sperling; D E Shapiro; R W Coombs; J A Todd; S A Herman; G D McSherry; M J O'Sullivan; R B Van Dyke; E Jimenez; C Rouzioux; P M Flynn; J L Sullivan
Journal:  N Engl J Med       Date:  1996-11-28       Impact factor: 91.245

3.  Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial.

Authors:  Isabelle de Vincenzi
Journal:  Lancet Infect Dis       Date:  2011-01-13       Impact factor: 25.071

4.  Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy.

Authors: 
Journal:  Clin Infect Dis       Date:  2005-01-07       Impact factor: 9.079

5.  Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study.

Authors:  Ibou Thior; Shahin Lockman; Laura M Smeaton; Roger L Shapiro; Carolyn Wester; S Jody Heymann; Peter B Gilbert; Lisa Stevens; Trevor Peter; Soyeon Kim; Erik van Widenfelt; Claire Moffat; Patrick Ndase; Peter Arimi; Poloko Kebaabetswe; Patson Mazonde; Joseph Makhema; Kenneth McIntosh; Vladimir Novitsky; Tun-Hou Lee; Richard Marlink; Stephen Lagakos; Max Essex
Journal:  JAMA       Date:  2006-08-16       Impact factor: 56.272

6.  A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators.

Authors:  M Lallemant; G Jourdain; S Le Coeur; S Kim; S Koetsawang; A M Comeau; W Phoolcharoen; M Essex; K McIntosh; V Vithayasai
Journal:  N Engl J Med       Date:  2000-10-05       Impact factor: 91.245

7.  Early diagnosis of human immunodeficiency virus in infants using polymerase chain reaction on dried blood spots in Botswana's national program for prevention of mother-to-child transmission.

Authors:  Tracy Creek; Amilcar Tanuri; Monica Smith; Khumo Seipone; Molly Smit; Keitumetse Legwaila; Catherine Motswere; Maruping Maruping; Tapologo Nkoane; Ralph Ntumy; Ebi Bile; Madisa Mine; Lydia Lu; Goitebetswe Tebele; Loeto Mazhani; Margarett K Davis; Thierry H Roels; Peter H Kilmarx; Nathan Shaffer
Journal:  Pediatr Infect Dis J       Date:  2008-01       Impact factor: 2.129

8.  Quantification of HIV-1 virus load under zidovudine therapy in patients with symptomatic HIV infection: relation to disease progression.

Authors:  J M Molina; F Ferchal; S Chevret; V Barateau; C Poirot; F Morinet; J Modai
Journal:  AIDS       Date:  1994-01       Impact factor: 4.177

9.  Treatment acceleration program and the experience of the DREAM program in prevention of mother-to-child transmission of HIV.

Authors:  Leonardo Palombi; Maria Cristina Marazzi; Albertus Voetberg; N Abdul Magid
Journal:  AIDS       Date:  2007-07       Impact factor: 4.177

10.  Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach.

Authors:  Besigin Tonwe-Gold; Didier K Ekouevi; Ida Viho; Clarisse Amani-Bosse; Siaka Toure; Patrick A Coffie; François Rouet; Renaud Becquet; Valériane Leroy; Wafaa M El-Sadr; Elaine J Abrams; François Dabis
Journal:  PLoS Med       Date:  2007-08       Impact factor: 11.069
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  12 in total

1.  HIV in Africa: Challenges and Directions for the Next Decade.

Authors:  Bruce L Gilliam; Devang Patel; Rohit Talwani; Zelalem Temesgen
Journal:  Curr Infect Dis Rep       Date:  2012-02       Impact factor: 3.725

2.  Initial programmatic implementation of WHO option B in Botswana associated with increased projected MTCT.

Authors:  Scott Dryden-Peterson; Shahin Lockman; Rebecca Zash; Quonhong Lei; Jennifer Y Chen; Sajini Souda; Chipo Petlo; Eldah Dintwa; Refeletswe Lebelonyane; Mompati Mmalane; Roger L Shapiro
Journal:  J Acquir Immune Defic Syndr       Date:  2015-03-01       Impact factor: 3.731

Review 3.  Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.

Authors:  Benjamin H Chi; Jeffrey S A Stringer; Dhayendre Moodley
Journal:  Curr HIV/AIDS Rep       Date:  2013-06       Impact factor: 5.071

4.  Effectiveness of a prevention of mother-to-child HIV transmission programme in an urban hospital in Angola.

Authors:  Cristina Lussiana; Sofia Vanda Lôa Clemente; Angelo Ghelardi; Magda Lonardi; Ivan Alejandro Pulido Tarquino; Marco Floridia
Journal:  PLoS One       Date:  2012-04-30       Impact factor: 3.240

5.  Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV.

Authors:  Patumrat Sripan; Sophie Le Coeur; Billy Amzal; Lily Ingsrisawang; Patrinee Traisathit; Nicole Ngo-Giang-Huong; Kenneth McIntosh; Tim R Cressey; Suraphan Sangsawang; Boonsong Rawangban; Prateep Kanjanavikai; Jean-Marc Tréluyer; Gonzague Jourdain; Marc Lallemant; Saïk Urien
Journal:  PLoS One       Date:  2015-05-19       Impact factor: 3.240

Review 6.  Tracking the progress of HIV: the impact of point-of-care tests on antiretroviral therapy.

Authors:  Steven D Reid; Sarah J Fidler; Graham S Cooke
Journal:  Clin Epidemiol       Date:  2013-09-26       Impact factor: 4.790

7.  Retired Nurses Can Improve Retention in Prevention of Mother-to-Child Transmission Programmes.

Authors:  Zahra Persson Theilgaard; Mercy G Chiduo; Leo Flamholc; Jan Gerstoft; Ib C Bygbjerg; Martha Moshi Lemnge; Terese L Katzenstein
Journal:  East Afr Health Res J       Date:  2019-11-29

8.  Mother to Mother (M2M) peer support for women in Prevention of Mother to Child Transmission (PMTCT) programmes: a qualitative study.

Authors:  Amir Shroufi; Emma Mafara; Jean François Saint-Sauveur; Fabian Taziwa; Mari Carmen Viñoles
Journal:  PLoS One       Date:  2013-06-05       Impact factor: 3.240

9.  Maternal antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Malawi: maternal and infant outcomes two years after delivery.

Authors:  Marina Giuliano; Mauro Andreotti; Giuseppe Liotta; Haswell Jere; Jean-Baptiste Sagno; Martin Maulidi; Sandro Mancinelli; Ersilia Buonomo; Paola Scarcella; Maria F Pirillo; Roberta Amici; Susanna Ceffa; Stefano Vella; Leonardo Palombi; Maria Cristina Marazzi
Journal:  PLoS One       Date:  2013-07-19       Impact factor: 3.240

10.  Cotrimoxazole prophylaxis and risk of severe anemia or severe neutropenia in HAART-exposed, HIV-uninfected infants.

Authors:  Scott Dryden-Peterson; Oluwemimo Jayeoba; Michael D Hughes; Haruna Jibril; Kenneth McIntosh; Taolo A Modise; Aida Asmelash; Kathleen M Powis; Max Essex; Roger L Shapiro; Shahin Lockman
Journal:  PLoS One       Date:  2013-09-23       Impact factor: 3.240
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