Addendum to "Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential" [Mol. Immunol. 48(4) (2011) 497-504].

Measles virus (MV) V protein blocks type I IFN signaling in MV-infected cells. Previous studies suggested that some MV strains could release the V protein-mediated type I IFN suppression in affected cells by two distinct modes: V protein mutation and production of DI RNA. These two modes of type I interferon regulation involves the IPS-1 (MAVS, Cardif, VISA) pathway (Takaki et al., 2011. Mol. Immunol. 48(4), 497–504). We add the comment to this previous issue that the release of the V protein-mediated suppression of type I IFN occurs only by a laboratory-adapted strain of Edmonston.