H-J Meyer1, H Wilke.
Abstract
BACKGROUND: The overall prognosis of gastric cancer with an overall 5-year survival of 25% is still poor despite improvements of the surgical and perioperative procedures. To improve the surgical treatment results other therapeutic options as chemo- and/or radiotherapy have been investigated for more than 20 years.
METHODS: After a literature review, the results of actual trials of multimodality treatment were analysed and described.
RESULTS: Adjuvant treatment was less effective compared with neoadjuvant or perioperative chemotherapy performed in advanced tumour categories T3/4. Actual trials could show that the rate of curative (R0) resection can be augmented resulting in an increase of the overall 5-year survival rate of more than 10 %.
CONCLUSION: To confirm this trend, further studies with high pathological and surgical quality control are necessary as well as a more exact definition of prediction and evaluation of the response following chemotherapy. © Georg Thieme Verlag KG Stuttgart ˙ New York.
BACKGROUND: The overall prognosis of gastric cancer with an overall 5-year survival of 25% is still poor despite improvements of the surgical and perioperative procedures. To improve the surgical treatment results other therapeutic options as chemo- and/or radiotherapy have been investigated for more than 20 years.
METHODS: After a literature review, the results of actual trials of multimodality treatment were analysed and described.
RESULTS: Adjuvant treatment was less effective compared with neoadjuvant or perioperative chemotherapy performed in advanced tumour categories T3/4. Actual trials could show that the rate of curative (R0) resection can be augmented resulting in an increase of the overall 5-year survival rate of more than 10 %.
CONCLUSION: To confirm this trend, further studies with high pathological and surgical quality control are necessary as well as a more exact definition of prediction and evaluation of the response following chemotherapy. © Georg Thieme Verlag KG Stuttgart ˙ New York.
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Mesh：
Year: 2011
PMID： 21789757 DOI： 10.1055/s-0031-1271580
Source DB: PubMed Journal: Zentralbl Chir ISSN： 0044-409X Impact factor: 0.942