| Literature DB >> 21789618 |
Esther Guadalupe Corona-Sanchez1, José Francisco Muñoz-Valle, Laura Gonzalez-Lopez, Julia Dolores Sanchez-Hernandez, Monica Vazquez-Del Mercado, Heriberto Ontiveros-Mercado, Miguel Huerta, Xochitl Trujillo, Alberto Daniel Rocha-Muñoz, Alfredo Celis, Ricardo Ortega-Flores, Jorge Ivan Gamez-Nava.
Abstract
The objective of this study was to evaluate the differences in allele and genotype frequencies of -383 tumor necrosis factor receptor 1 (TNFR1) polymorphism between ankylosing spondylitis (AS) and controls. Mexican Mestizos with AS were matched by gender, age, and ethnicity with healthy controls and compared in allele and genotype frequencies of the -383 TNFR1 polymorphism. Polymorphisms were genotyped using PCR-RFLP. The AA genotype occurred at a higher frequency in the AS group (92%) compared with controls (79%, P = 0.03). A allele was increased in AS (96% vs. 88%, P = 0.015) and was associated with genetic susceptibility for AS (odds ratio = 3.48, 95% CI = 1.23-10.61). This preliminary study is the first assessing the association of the -383 A/C TNFR1 polymorphism with AS, although it has the limitation of a small sample size. These data are of interest for the genetic epidemiology of AS in the Mexican population, requiring further investigation in other countries.Entities:
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Year: 2011 PMID： 21789618 DOI： 10.1007/s00296-011-1997-5
Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631