| Literature DB >> 21789542 |
Xue Yuan1, Jianguo Wang, Xiaoyan Zhu, Zhigang Zhang, Yongxing Ai, Guoquan Sun, Zhe Wang, Guowen Liu.
Abstract
The effects of different concentrations of copper on collagen content and alkaline phosphatase (AKP) activity from chondrocytes in newborn piglets were measured. Chondrocytes were cultured in media containing 15% fetal calf serum supplemented with 0, 15.6, 31.2, and 62.5 μmol/L copper in a 12-well culture plate. Collagen content and AKP activity from the chondrocyte extracellular matrix increased significantly in the culture media with 15.6, 31.2, and 62.5 μmol/L copper and was the highest at 31.2 μmol/L copper (P < 0.05). Thus, the results indicated that copper could promote AKP activity and collagen production by chondrocytes.Entities:
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Year: 2011 PMID： 21789542 DOI： 10.1007/s12011-011-9151-5
Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738