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Literature DB >> 21789068

Overactive bladder in males.

Abstract

The prevalence of overactive bladder (OAB) symptoms is considerable in both men and women and the impact on quality of life (QOL) is equally substantial. Ironically, despite nearly equal prevalence, OAB symptoms in men are infrequently treated, and often with medical therapies aimed at bladder outlet obstruction (BOO). In this review, we examine the pathophysiology of OAB and its evaluation in the context of benign prostatic hypertrophy and concomitant BOO. We then consider the efficacy and safety of individual therapeutic options for lower urinary tract symptoms in men, focusing on the mainstays of medical therapy: α-adrenergic blockers, 5-α reductase inhibitors, and antimuscarinic agents. Finally, we aim to comment on new therapeutic strategies and targets that may one day be available for the treatment of male OAB.

Entities: Disease Species

Keywords: anticholinergic; benign prostatic hypertrophy; overactive bladder

Year: 2009 PMID： 21789068 PMCID： PMC3126063 DOI： 10.1177/1756287209350383

Source DB: PubMed Journal: Ther Adv Urol ISSN： 1756-2872

87 in total

1. A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction.

Authors: B A O'Reilly; A H Kosaka; T K Chang; A P Ford; R Popert; S B McMahon
Journal: BJU Int Date: 2001-05 Impact factor: 5.588

Review 2. Effect of bladder outlet obstruction on the morphology, physiology, and pharmacology of the bladder.

Authors: R M Levin; P A Longhurst; F C Monson; K Kato; A J Wein
Journal: Prostate Suppl Date: 1990

3. Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo.

Authors: George J Christ; Nancy S Day; Michele Day; Weixin Zhao; Katarina Persson; Raj K Pandita; Karl-Erik Andersson
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-05 Impact factor: 3.619

4. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study.

Authors: Debra E Irwin; Ian Milsom; Steinar Hunskaar; Kate Reilly; Zoe Kopp; Sender Herschorn; Karin Coyne; Con Kelleher; Christian Hampel; Walter Artibani; Paul Abrams
Journal: Eur Urol Date: 2006-10-02 Impact factor: 20.096

5. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia.

Authors: John D McConnell; Claus G Roehrborn; Oliver M Bautista; Gerald L Andriole; Christopher M Dixon; John W Kusek; Herbert Lepor; Kevin T McVary; Leroy M Nyberg; Harry S Clarke; E David Crawford; Ananias Diokno; John P Foley; Harris E Foster; Stephen C Jacobs; Steven A Kaplan; Karl J Kreder; Michael M Lieber; M Scott Lucia; Gary J Miller; Mani Menon; Douglas F Milam; Joe W Ramsdell; Noah S Schenkman; Kevin M Slawin; Joseph A Smith
Journal: N Engl J Med Date: 2003-12-18 Impact factor: 91.245

6. A case-control study of risk factors in men with chronic pelvic pain syndrome.

Authors: Michel A Pontari; Mary McNaughton-Collins; Michael P O'leary; Elizabeth A Calhoun; Thomas Jang; John W Kusek; J Richard Landis; Jill Knauss; Mark S Litwin
Journal: BJU Int Date: 2005-09 Impact factor: 5.588

7. Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study.

Authors: Yoshinori Nishino; Takako Masue; Kousei Miwa; Yoshito Takahashi; Satoshi Ishihara; Takashi Deguchi
Journal: BJU Int Date: 2006-04 Impact factor: 5.588

8. Tamsulosin, a selective alpha 1c-adrenoceptor antagonist: a randomized, controlled trial in patients with benign prostatic 'obstruction' (symptomatic BPH). The European Tamsulosin Study Group.

Authors: P Abrams; C C Schulman; S Vaage
Journal: Br J Urol Date: 1995-09

4. Efficacy of anticholinergics for chronic prostatitis/chronic pelvic pain syndrome in young and middle-aged patients: a single-blinded, prospective, multi-center study.

Authors: Doo Sang Kim; Yoon Soo Kyung; Seung Hyo Woo; Young Seop Chang; Hyung-Jee Kim
Journal: Int Neurourol J Date: 2011-09-30 Impact factor: 2.835

Review 5. Current role of treatment in men with lower urinary tract symptoms combined with overactive bladder.

Authors: Seung Hwan Lee; Ji Youl Lee
Journal: Prostate Int Date: 2014-06-30

5 in total

Overactive bladder in males.

1. A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction.

Review 2. Effect of bladder outlet obstruction on the morphology, physiology, and pharmacology of the bladder.

3. Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo.

4. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study.

5. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia.

6. A case-control study of risk factors in men with chronic pelvic pain syndrome.

7. Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study.

8. Tamsulosin, a selective alpha 1c-adrenoceptor antagonist: a randomized, controlled trial in patients with benign prostatic 'obstruction' (symptomatic BPH). The European Tamsulosin Study Group.

9. Bother related to bladder control and health care seeking behavior in adults in the United States.

10. Costs of urinary incontinence and overactive bladder in the United States: a comparative study.

1. Inhibition of NMDAR reduces bladder hypertrophy and improves bladder function in cyclophosphamide induced cystitis.

2. PATTERN OF OVERACTIVE BLADDER IN SOUTHEAST NIGERIA.

3. Usage results of a mobile app for managing urinary incontinence.

4. Efficacy of anticholinergics for chronic prostatitis/chronic pelvic pain syndrome in young and middle-aged patients: a single-blinded, prospective, multi-center study.

Review 5. Current role of treatment in men with lower urinary tract symptoms combined with overactive bladder.