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Literature DB >> 21787310

The mitochondrial citrate carrier: a new player in inflammation.

Vittoria Infantino¹, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, Rosa Calvello, Ferdinando Palmieri, Vito Iacobazzi.

Abstract

The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21787310 DOI： 10.1042/BJ20111275

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

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Cited

121 in total

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Review 2. A guide to immunometabolism for immunologists.

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3. Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.

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Journal: J Biol Chem Date: 2018-01-09 Impact factor: 5.157

Review 4. The bioenergetics of inflammation: insights into obesity and type 2 diabetes.

Authors: K N Keane; E K Calton; R Carlessi; P H Hart; P Newsholme
Journal: Eur J Clin Nutr Date: 2017-04-12 Impact factor: 4.016

5. Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes.

Authors: Maiken Mellergaard; Rikke Illum Høgh; Astrid Lund; Blanca Irene Aldana; Romain Guérillot; Sofie Hedlund Møller; Ashleigh S Hayes; Nafsika Panagiotopoulou; Zofija Frimand; Stine Dam Jepsen; Camilla Hartmann Friis Hansen; Lars Andresen; Anders Rhod Larsen; Anton Y Peleg; Timothy P Stinear; Benjamin P Howden; Helle S Waagepetersen; Dorte Frees; Søren Skov
Journal: J Biol Chem Date: 2020-06-30 Impact factor: 5.157

The mitochondrial citrate carrier: a new player in inflammation.

Review 1. Immunometabolism: Cellular Metabolism Turns Immune Regulator.

Review 2. A guide to immunometabolism for immunologists.

3. Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.

Review 4. The bioenergetics of inflammation: insights into obesity and type 2 diabetes.

5. Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes.

Review 6. Mitochondria are the powerhouses of immunity.

Review 7. Metabolism of inflammation limited by AMPK and pseudo-starvation.

Review 8. Citrate chemistry and biology for biomaterials design.

Review 9. HIF1α and metabolic reprogramming in inflammation.

Review 10. The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.