OBJECTIVE: To test the null hypothesis that there is no difference in mandibular growth between growing rats with posterior functional mandibular displacement and growing rats without functional mandibular displacement. MATERIALS AND METHODS: Twenty female Wistar rats (5 weeks old) were randomized into two groups: (1) control and (2) mandible posterior displacement in the occluded condition induced by an occlusal guiding appliance. After 8 weeks all animals were sacrificed, cone beam computed tomography scan images of the heads were taken using the classic I-CAT, and acrylic rapid-prototyped templates of the mandibles were constructed. Mandibular length, ramus height, and intercondylar distance were measured. Mandibular length and ramus height were submitted to the two-way analysis of variance, while intercondylar distance was analyzed by nonpaired Student's t-test. RESULTS: Mandibular length was bigger (P < .0001) in the control than in the experimental group, but no significant difference was found between the left and right sides (P = .9380). No significant differences were observed for ramus height and intercondylar distance. CONCLUSIONS: The results of this study demonstrated that functional posterior displacement of the mandible in growing rats resulted in shorter mandibular length.
OBJECTIVE: To test the null hypothesis that there is no difference in mandibular growth between growing rats with posterior functional mandibular displacement and growing rats without functional mandibular displacement. MATERIALS AND METHODS: Twenty female Wistar rats (5 weeks old) were randomized into two groups: (1) control and (2) mandible posterior displacement in the occluded condition induced by an occlusal guiding appliance. After 8 weeks all animals were sacrificed, cone beam computed tomography scan images of the heads were taken using the classic I-CAT, and acrylic rapid-prototyped templates of the mandibles were constructed. Mandibular length, ramus height, and intercondylar distance were measured. Mandibular length and ramus height were submitted to the two-way analysis of variance, while intercondylar distance was analyzed by nonpaired Student's t-test. RESULTS: Mandibular length was bigger (P < .0001) in the control than in the experimental group, but no significant difference was found between the left and right sides (P = .9380). No significant differences were observed for ramus height and intercondylar distance. CONCLUSIONS: The results of this study demonstrated that functional posterior displacement of the mandible in growing rats resulted in shorter mandibular length.
Authors: Helmtrud I Roach; Gautam Mehta; Richard O C Oreffo; Nicholas M P Clarke; Cyrus Cooper Journal: J Histochem Cytochem Date: 2003-03 Impact factor: 2.479