Literature DB >> 21786359

Self-Assembly Pluronic and β-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery.

Min-Min Fan1, Xi Zhang1, Jie Qin1, Bang-Jing Li2, Xun Sun3, Sheng Zhang4.   

Abstract

This paper studies a kind of hollow nanospheres prepared by self-assembly β-cyclodextrins (β-CDs) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic F127) for gene delivery. It was found that this kind of hollow nanospheres enable load PEI10K/DNA and the resulting F127NH2 βCD/(PEI10K/DNA) with 0.08 µg/well DNA display equal or higher gene delivery capability compared to PEI10K/DNA with 1 µg/well DNA in the absence or presence of serum. The cytotoxicity of the nanospheres was over 100 times lower than that of PEI10K.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cyclodextrins; dendrimer; gene delivery; self-assembly; supramolecular hollow nanospheres

Mesh：

Substances：

Year:  2011        PMID： 21786359     DOI： 10.1002/marc.201100272

Source DB:  PubMed          Journal:  Macromol Rapid Commun        ISSN： 1022-1336            Impact factor:   5.734


  4 in total

1.  Hollow micro and nanostructures for therapeutic and imaging applications.

Authors:  Emir Yasun; Sonu Gandhi; Samraggi Choudhury; Reza Mohammadinejad; Farah Benyettou; Numan Gozubenli; Hamed Arami
Journal:  J Drug Deliv Sci Technol       Date:  2020-09-14       Impact factor: 3.981

2.  Pentablock copolymers of pluronic F127 and modified poly(2-dimethyl amino)ethyl methacrylate for internalization mechanism and gene transfection studies.

Authors:  Shih-Jer Huang; Tzu-Pin Wang; Sheng-I Lue; Li-Fang Wang
Journal:  Int J Nanomedicine       Date:  2013-05-27

3.  Loose-fit polypseudorotaxanes constructed from γ-CDs and PHEMA-PPG-PEG-PPG-PHEMA.

Authors:  Tao Kong; Lin Ye; Ai-Ying Zhang; Zeng-Guo Feng
Journal:  Beilstein J Org Chem       Date:  2014-10-23       Impact factor: 2.883

4.  Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic®/Hyaluronate Hydrogel.

Authors:  Ana-María Fernández-Romero; Francesca Maestrelli; Sara García-Gil; Elena Talero; Paola Mura; Antonio M Rabasco; María Luisa González-Rodríguez
Journal:  Int J Mol Sci       Date:  2021-12-17       Impact factor: 5.923
  4 in total

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