Yang-Mei Shen1, Gunnar Arbman, Birgit Olsson, Xiao-Feng Sun. 1. Division of Oncology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Linköping - Sweden and Department of Pathology, West China Second University Hospital, SiChuan University, Chengdu - China.
Abstract
BACKGROUND: To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables. METHODS: The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. RESULTS: The mean value of GLUT1 was higher in primary tumors (50.390 ± 68.648) than in the corresponding normal mucosa (20.437 ± 28.703, p<0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 ± 68.648 vs 52.277 ± 52.482, p=0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p=0.022), and higher in stage III + IV than in stage I + II tumors (p=0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p=0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p=0.025). CONCLUSIONS: Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
BACKGROUND: To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables. METHODS: The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. RESULTS: The mean value of GLUT1 was higher in primary tumors (50.390 ± 68.648) than in the corresponding normal mucosa (20.437 ± 28.703, p<0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 ± 68.648 vs 52.277 ± 52.482, p=0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p=0.022), and higher in stage III + IV than in stage I + II tumors (p=0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p=0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p=0.025). CONCLUSIONS: Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
Authors: Hans Anton Schlößer; Uta Drebber; Alexander Urbanski; Simon Haase; Christoph Baltin; Felix Berlth; Susanne Neiß; Michael von Bergwelt-Baildon; Ulrich Klaus Fetzner; Ute Warnecke-Eberz; Elfriede Bollschweiler; Arnulf Heinrich Hölscher; Stefan Paul Mönig; Hakan Alakus Journal: Gastric Cancer Date: 2015-12-07 Impact factor: 7.370
Authors: Alessia Mira; Virginia Morello; Maria Virtudes Céspedes; Timothy Perera; Paolo M Comoglio; Ramon Mangues; Paolo Michieli Journal: Oncotarget Date: 2017-06-13
Authors: Mart Dela Cruz; Sarah Ledbetter; Sanjib Chowdhury; Ashish K Tiwari; Navneet Momi; Ramesh K Wali; Charles Bliss; Christopher Huang; David Lichtenstein; Swati Bhattacharya; Anisha Varma-Wilson; Vadim Backman; Hemant K Roy Journal: Oncotarget Date: 2017-03-28