Literature DB >> 21786216

Investigation of amygdala volume in men with the fragile X premutation.

Diana Selmeczy1, Kami Koldewyn, John M Wang, Aaron Lee, Danielle Harvey, David R Hessl, Flora Tassone, Patrick Adams, Randi J Hagerman, Paul J Hagerman, Susan M Rivera.   

Abstract

Premutation fragile X carriers have a CGG repeat expansion (55 to 200 repeats) in the promoter region of the fragile X mental retardation 1 (FMR1) gene. Amygdala dysfunction has been observed in premutation symptomatology, and recent research has suggested the amygdala as an area susceptible to the molecular effects of the premutation. The current study utilizes structural magnetic resonance imaging (MRI) to examine the relationship between amygdala volume, CGG expansion size, FMR1 mRNA, and psychological symptoms in male premutation carriers without FXTAS compared with age and IQ matched controls. No significant between group differences in amygdala volume were found. However, a significant negative correlation between amygdala volume and CGG was found in the lower range of CGG repeat expansions, but not in the higher range of CGG repeat expansions.

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Year:  2011        PMID： 21786216      PMCID： PMC3982607          DOI： 10.1007/s11682-011-9132-5

Source DB:  PubMed          Journal:  Brain Imaging Behav        ISSN： 1931-7557            Impact factor:   3.978


  58 in total

1.  Premature ovarian failure among fragile X premutation carriers: parent-of-origin effect?

Authors:  S L Sherman
Journal:  Am J Hum Genet       Date:  2000-06-12       Impact factor: 11.025

2.  Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation.

Authors:  Faraz Farzin; Hazel Perry; David Hessl; Danuta Loesch; Jonathan Cohen; Susan Bacalman; Louise Gane; Flora Tassone; Paul Hagerman; Randi Hagerman
Journal:  J Dev Behav Pediatr       Date:  2006-04       Impact factor: 2.225

3.  Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation.

Authors:  David Hessl; Flora Tassone; Danuta Z Loesch; Elizabeth Berry-Kravis; Maureen A Leehey; Louise W Gane; Ingrid Barbato; Cathlin Rice; Emma Gould; Deborah A Hall; James Grigsby; Jacob A Wegelin; Susan Harris; Foster Lewin; Dahlia Weinberg; Paul J Hagerman; Randi J Hagerman
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2005-11-05       Impact factor: 3.568

4.  Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain.

Authors:  M Abitbol; C Menini; A L Delezoide; T Rhyner; M Vekemans; J Mallet
Journal:  Nat Genet       Date:  1993-06       Impact factor: 38.330

5.  FMRP expression as a potential prognostic indicator in fragile X syndrome.

Authors:  F Tassone; R J Hagerman; D N Iklé; P N Dyer; M Lampe; R Willemsen; B A Oostra; A K Taylor
Journal:  Am J Med Genet       Date:  1999-05-28

6.  The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy.

Authors:  Caroline J Moore; Eileen M Daly; Flora Tassone; Carolyn Tysoe; Nicole Schmitz; Virginia Ng; Xavier Chitnis; Philip McGuire; John Suckling; Kay E Davies; Randi J Hagerman; Paul J Hagerman; Kieran C Murphy; Declan G M Murphy
Journal:  Brain       Date:  2004-10-13       Impact factor: 13.501

7.  The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages.

Authors:  Cynthia Mills Schumann; Julia Hamstra; Beth L Goodlin-Jones; Linda J Lotspeich; Hower Kwon; Michael H Buonocore; Cathy R Lammers; Allan L Reiss; David G Amaral
Journal:  J Neurosci       Date:  2004-07-14       Impact factor: 6.167

Review 8.  The fragile-X premutation: a maturing perspective.

Authors:  Paul J Hagerman; Randi J Hagerman
Journal:  Am J Hum Genet       Date:  2004-03-29       Impact factor: 11.025

Review 9.  The FMR1 gene and fragile X-associated tremor/ataxia syndrome.

Authors:  J R Brouwer; R Willemsen; B A Oostra
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-09-05       Impact factor: 3.568

10.  Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation.

Authors:  Kami Koldewyn; David Hessl; John Adams; Flora Tassone; Paul J Hagerman; Randi J Hagerman; Susan M Rivera
Journal:  Brain Imaging Behav       Date:  2008-01-18       Impact factor: 3.978
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  3 in total

Review 1.  Fragile X-associated tremor/ataxia syndrome: phenotypic comparisons with other movement disorders.

Authors:  Erin E Robertson; Deborah A Hall; Andrew R McAsey; Joan A O'Keefe
Journal:  Clin Neuropsychol       Date:  2016-08       Impact factor: 3.535

2.  COGNITIVE DYSFUNCTION IN FMR1 PREMUTATION CARRIERS.

Authors:  Andreea Seritan; Jennifer Cogswell; Jim Grigsby
Journal:  Curr Psychiatry Rev       Date:  2013-02

3.  Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism.

Authors:  Molly Losh; Jessica Klusek; Gary E Martin; John Sideris; Morgan Parlier; Joseph Piven
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-06-12       Impact factor: 3.568
  3 in total

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